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LMAN1, Antibody

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LMAN1, Antibody


LMAN1, Antibody  的詳細(xì)介紹
Product Name

LMAN1, Antibody

Full Product Name

LMAN1 Antibody

Product Gene Name

anti-LMAN1 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
X71661 mRNA
3D Structure
ModBase 3D Structure for P49257
Host
Rabbit
Species Reactivity
Human, Mouse
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-LMAN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Applications Tested/Suitable for anti-LMAN1 antibody
Western Blot (WB)
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NCBI/Uniprot data below describe general gene information for LMAN1. It may not necessarily be applicable to this product.
NCBI GI #
5031873
NCBI GeneID
3998
NCBI Accession #
NP_005561.1 [Other Products]
NCBI GenBank Nucleotide #
NM_005570.3 [Other Products]
UniProt Primary Accession #
P49257 [Other Products]
UniProt Secondary Accession #
Q12895; Q8N5I7; Q9UQG1; Q9UQG2; Q9UQG3; Q9UQG4; Q9UQG5; Q9UQG6; Q9UQG7; Q9UQG8; Q9UQG9[Other Products]
UniProt Related Accession #
P49257[Other Products]
Molecular Weight
57,549 Da
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NCBI Official Full Name
protein ERGIC-53
NCBI Official Synonym Full Names
lectin, mannose binding 1
NCBI Official Symbol
LMAN1??[Similar Products]
NCBI Official Synonym Symbols
MR60; gp58; F5F8D; FMFD1; MCFD1; ERGIC53; ERGIC-53
??[Similar Products]
NCBI Protein Information
protein ERGIC-53
UniProt Protein Name
Protein ERGIC-53
UniProt Synonym Protein Names
ER-Golgi intermediate compartment 53 kDa protein; Gp58; Intracellular mannose-specific lectin MR60; Lectin mannose-binding 1
Protein Family
Protein
UniProt Gene Name
LMAN1??[Similar Products]
UniProt Synonym Gene Names
ERGIC53; F5F8D??[Similar Products]
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NCBI Summary for LMAN1
The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]
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UniProt Comments for LMAN1
LMAN1: Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Defects in LMAN1 are THE cause of factor V and factor VIII combined deficiency type 1 (F5F8D1); also known as multiple coagulation factor deficiency I (MCFD1). F5F8D1 is an autosomal recessive blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q21.32

Cellular Component: endoplasmic reticulum membrane; ER to Golgi transport vesicle; ER-Golgi intermediate compartment; ER-Golgi intermediate compartment membrane; membrane

Molecular Function: protein binding; unfolded protein binding

Biological Process: blood coagulation; COPII coating of Golgi vesicle; endoplasmic reticulum organization and biogenesis; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; protein amino acid N-linked glycosylation via asparagine; protein exit from endoplasmic reticulum; protein folding

Disease: Factor V And Factor Viii, Combined Deficiency Of, 1
Research Articles on LMAN1
1. Mannan-binding lectin reduces CpG DNA-induced inflammatory cytokine production in monocytes.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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