Product Name
OXCT1, Blocking Peptide
Full Product Name
OXCT1 Blocking Peptide (Center)
Product Synonym Names
Succinyl-CoA:3-ketoacid coenzyme A transferase 1; mitochondrial; 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s; OXCT1; OXCT; SCOT
Product Gene Name
OXCT1 blocking peptide
[Similar Products]
Product Synonym Gene Name
OXCT; SCOT[Similar Products]
OXCT1 peptide (MBS9230068) is used for blocking the activity of OXCT1 antibody (MBS9206440)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P55809
Specificity
The synthetic peptide sequence is selected from aa 272-286 of HUMAN OXCT1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Mitochondrion matrix.
Tissue Location
Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of OXCT1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
OXCT1 blocking peptide
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
NCBI/Uniprot data below describe general gene information for OXCT1. It may not necessarily be applicable to this product.
NCBI Accession #
P55809.1
[Other Products]
UniProt Primary Accession #
P55809
[Other Products]
UniProt Secondary Accession #
B2R5V2; B7Z528[Other Products]
UniProt Related Accession #
P55809[Other Products]
Molecular Weight
13,358 Da
NCBI Official Full Name
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
NCBI Official Synonym Full Names
3-oxoacid CoA-transferase 1
NCBI Official Symbol
OXCT1??[Similar Products]
NCBI Official Synonym Symbols
OXCT; SCOT
??[Similar Products]
NCBI Protein Information
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
UniProt Protein Name
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
UniProt Synonym Protein Names
3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s
Protein Family
Succinyl-CoA:3-ketoacid coenzyme A transferase
UniProt Gene Name
OXCT1??[Similar Products]
UniProt Synonym Gene Names
OXCT; SCOT; SCOT-s??[Similar Products]
UniProt Entry Name
SCOT1_HUMAN
NCBI Summary for OXCT1
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for OXCT1
OXCT1: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. Defects in OXCT1 are a cause of succinyl-CoA-3-ketoacid- CoA transferase deficiency (SCOTD). A disorder of ketone body metabolism, characterized by episodic ketoacidosis. Patients are usually asymptomatic between episodes. Belongs to the 3-oxoacid CoA-transferase family.
Protein type: Mitochondrial; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Transferase; Lipid Metabolism - synthesis and degradation of ketone bodies; EC 2.8.3.5
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: 3-oxoacid CoA-transferase activity
Biological Process: ketone body catabolic process; ketone body metabolic process
Disease: Succinyl-coa:3-oxoacid Coa Transferase Deficiency
Research Articles on OXCT1
1. Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects.
Precautions
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Disclaimer
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