Full Product Name
OXCT1 Antibody
Product Synonym Names
OXCT; SCOT
Product Gene Name
anti-OXCT1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P55809
Specificity
The antibody detects endogenous levels of total OXCT1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
1.3 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to residues near the C terminal of human 3-oxoacid CoA transferase 1
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-OXCT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-OXCT1 antibody
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency.
Product Categories/Family for anti-OXCT1 antibody
Total protein Ab
Applications Tested/Suitable for anti-OXCT1 antibody
Western Blot (WB)
Application Notes for anti-OXCT1 antibody
Western blotting: 1:500-1:2000
Testing Data of anti-OXCT1 antibody
Gel: 8%SDS-PAGE Lysate: 40ug Hela cellPrimary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 seconds

NCBI/Uniprot data below describe general gene information for OXCT1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000427.1
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NCBI GenBank Nucleotide #
NM_000436.3
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UniProt Primary Accession #
P55809
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UniProt Secondary Accession #
B2R5V2; B7Z528[Other Products]
UniProt Related Accession #
P55809[Other Products]
Molecular Weight
13,358 Da
NCBI Official Full Name
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
NCBI Official Synonym Full Names
3-oxoacid CoA transferase 1
NCBI Official Symbol
OXCT1??[Similar Products]
NCBI Official Synonym Symbols
OXCT; SCOT
??[Similar Products]
NCBI Protein Information
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
UniProt Protein Name
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
UniProt Synonym Protein Names
3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s
Protein Family
Succinyl-CoA:3-ketoacid coenzyme A transferase
UniProt Gene Name
OXCT1??[Similar Products]
UniProt Synonym Gene Names
OXCT; SCOT; SCOT-s??[Similar Products]
UniProt Entry Name
SCOT1_HUMAN
NCBI Summary for OXCT1
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for OXCT1
OXCT1: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. Defects in OXCT1 are a cause of succinyl-CoA-3-ketoacid- CoA transferase deficiency (SCOTD). A disorder of ketone body metabolism, characterized by episodic ketoacidosis. Patients are usually asymptomatic between episodes. Belongs to the 3-oxoacid CoA-transferase family.
Protein type: Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; Lipid Metabolism - synthesis and degradation of ketone bodies; Transferase; EC 2.8.3.5
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: protein homodimerization activity; 3-oxoacid CoA-transferase activity
Biological Process: response to drug; response to starvation; response to ethanol; heart development; ketone body catabolic process; response to hormone stimulus; ketone catabolic process; brain development; cellular lipid metabolic process; ketone body metabolic process; response to activity; response to nutrient
Disease: Succinyl-coa:3-oxoacid Coa Transferase Deficiency
Research Articles on OXCT1
1. Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects.
Precautions
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