Full Product Name
OXCT1 Rabbit Polyclonal
Product Gene Name
anti-OXCT1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
3-oxoacid CoA transferase 1
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-OXCT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-OXCT1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for OXCT1. It may not necessarily be applicable to this product.
NCBI Accession #
AKI69742.1
[Other Products]
UniProt Secondary Accession #
B2R5V2; B7Z528[Other Products]
UniProt Related Accession #
P55809[Other Products]
Molecular Weight
13,358 Da
NCBI Official Full Name
OXCT1, partial
NCBI Official Synonym Full Names
3-oxoacid CoA-transferase 1
NCBI Official Symbol
OXCT1??[Similar Products]
NCBI Official Synonym Symbols
OXCT; SCOT
??[Similar Products]
NCBI Protein Information
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
UniProt Protein Name
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
UniProt Synonym Protein Names
3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s
Protein Family
Succinyl-CoA:3-ketoacid coenzyme A transferase
UniProt Gene Name
OXCT1??[Similar Products]
UniProt Synonym Gene Names
OXCT; SCOT; SCOT-s??[Similar Products]
UniProt Entry Name
SCOT1_HUMAN
NCBI Summary for OXCT1
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for OXCT1
OXCT1: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. Defects in OXCT1 are a cause of succinyl-CoA-3-ketoacid- CoA transferase deficiency (SCOTD). A disorder of ketone body metabolism, characterized by episodic ketoacidosis. Patients are usually asymptomatic between episodes. Belongs to the 3-oxoacid CoA-transferase family.
Protein type: Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; Lipid Metabolism - synthesis and degradation of ketone bodies; EC 2.8.3.5; Transferase
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: 3-oxoacid CoA-transferase activity; protein homodimerization activity
Biological Process: brain development; heart development; ketone body catabolic process; ketone body metabolic process; ketone catabolic process; response to activity; response to drug; response to ethanol; response to hormone stimulus; response to nutrient; response to starvation
Disease: Succinyl-coa:3-oxoacid Coa Transferase Deficiency
Research Articles on OXCT1
1. Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects.
Precautions
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