Product Name
ANK1, cDNA Clone
Full Product Name
ANK1 cDNA Clone
Product Gene Name
ANK1 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtggactt tcgtcaccca gctgttggtc acgctggtgc tgctgagctt cttcctggtc agctgtcaga acgtgatgca cattgtcagg gggtccctgt gctttgtgct aaagcacatc caccaggagc tggacaagga gctgggggag agcgaggacc tcagtgacga cgaggagacc atctccacca gggtggtccg gcggcgggtc ttcctgaagg ggaatgagtt tcagaatatt ccaggggagc aggtgacaga ggagcaattc acggatgagc agggcaacat tgtcaccaag aagatcattc gcaaggtggt tcgacagata gacttgtcca gcgccgatgc cgcccaggag cacgaggagg tggagctgag agggagtggc ctacagccgg acctgataga gggcaggaag ggggcgcaga tagtgaagcg ggccagcctg aaaaggggga aacagtga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ANK1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ANK1. It may not necessarily be applicable to this product.
NCBI Accession #
BC030957
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UniProt Secondary Accession #
O43400; Q13768; Q53ER1; Q59FP2; Q8N604; Q99407; A0PJN8; A6NJ23; E5RFL7[Other Products]
UniProt Related Accession #
P16157[Other Products]
Molecular Weight
17,854 Da
NCBI Official Full Name
Homo sapiens ankyrin 1, erythrocytic, mRNA
NCBI Official Synonym Full Names
ankyrin 1
NCBI Official Symbol
ANK1??[Similar Products]
NCBI Official Synonym Symbols
ANK; SPH1; SPH2
??[Similar Products]
NCBI Protein Information
ankyrin-1
UniProt Protein Name
Ankyrin-1
UniProt Synonym Protein Names
Ankyrin-R; Erythrocyte ankyrin
UniProt Gene Name
ANK1??[Similar Products]
UniProt Synonym Gene Names
ANK; ANK-1??[Similar Products]
UniProt Entry Name
ANK1_HUMAN
NCBI Summary for ANK1
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
UniProt Comments for ANK1
ANK1: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Defects in ANK1 are a cause of spherocytosis type 1 (SPH1); also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive. 21 isoforms of the human protein are produced by alternative promoter.
Protein type: Adaptor/scaffold; Cell development/differentiation; Endoplasmic reticulum; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8p11.1
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: ATPase binding; cytoskeletal adaptor activity; enzyme binding; protein binding; spectrin binding; structural constituent of cytoskeleton
Biological Process: ER to Golgi vesicle-mediated transport; maintenance of epithelial cell polarity
Disease: Spherocytosis, Type 1
Research Articles on ANK1
1. analysis of a novel p.Q1772X ANK1 mutation in a Korean family with hereditary spherocytosis [case report of two family members]
Precautions
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Disclaimer
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