Product Name
Synaptopodin-2 (SYNPO2), Recombinant Protein
Full Product Name
Recombinant Human Synaptopodin-2 (SYNPO2) , partial
Product Gene Name
SYNPO2 recombinant protein
[Similar Products]
Product Synonym Gene Name
SYNPO2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UMS6
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SYNPO2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SYNPO2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001122405.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001128933.2
[Other Products]
UniProt Primary Accession #
Q9UMS6
[Other Products]
UniProt Secondary Accession #
Q9UK89; B2RWP6; B2Y8J9; C6H0M7; S5XAM4[Other Products]
UniProt Related Accession #
Q9UMS6[Other Products]
Molecular Weight
74,762 Da
NCBI Official Full Name
synaptopodin-2 isoform b
NCBI Official Synonym Full Names
synaptopodin 2
NCBI Official Symbol
SYNPO2??[Similar Products]
NCBI Protein Information
synaptopodin-2
UniProt Protein Name
Synaptopodin-2
UniProt Synonym Protein Names
Genethonin-2; Myopodin
Protein Family
Synaptopodin
UniProt Gene Name
SYNPO2??[Similar Products]
UniProt Comments for SYNPO2
Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).
Research Articles on SYNPO2
1. These findings uncover a suppressive role of SYNPO2 in triple-negative breast cancer (TNBC) metastasis via inhibition of YAP/TAZ, and suggest that SYNPO2 might provide a potential prognosis marker and novel therapeutic strategy.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
