Full Product Name
Goat anti-GPX6 Antibody
Product Synonym Names
GPX6; glutathione peroxidase 6 (olfactory); HGNC: 4558; glutathione peroxidase 6; GPX6 antibody; glutathione peroxidase 6 (olfactory) antibody; HGNC: 4558 antibody; glutathione peroxidase 6 antibody
Product Gene Name
anti-GPX6 antibody
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Antibody/Peptide Pairs
GPX6 peptide (MBS425757) is used for blocking the activity of GPX6 antibody (MBS420565)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
QTLKPQNRKV DC
Species Reactivity
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence QTLKPQNRKVDC, from the internal region of the protein sequence according to NP_874360.1.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-GPX6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GPX6 antibody
Peptide ELISA (EIA)
Application Notes for anti-GPX6 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Preliminary experiments gave an approx 37kDa band in lysates of cell lines HepG2 and HeLa after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 24.9kDa according to NP_874360.1. The 37kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for GPX6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_874360.1
[Other Products]
NCBI GenBank Nucleotide #
NM_182701.1
[Other Products]
UniProt Secondary Accession #
Q4PJ17[Other Products]
UniProt Related Accession #
P59796[Other Products]
Molecular Weight
24,971 Da
NCBI Official Full Name
glutathione peroxidase 6
NCBI Official Synonym Full Names
glutathione peroxidase 6
NCBI Official Symbol
GPX6??[Similar Products]
NCBI Official Synonym Symbols
GPX5p; GPXP3; GPx-6; GSHPx-6; dJ1186N24; dJ1186N24.1
??[Similar Products]
NCBI Protein Information
glutathione peroxidase 6
UniProt Protein Name
Glutathione peroxidase 6
Protein Family
Glutathione peroxidase
UniProt Gene Name
GPX6??[Similar Products]
UniProt Synonym Gene Names
GPx-6; GSHPx-6??[Similar Products]
UniProt Entry Name
GPX6_HUMAN
NCBI Summary for GPX6
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and ***** olfactory epithelium. [provided by RefSeq, Jul 2008]
UniProt Comments for GPX6
GPX6: this protein belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and ***** olfactory epithelium. [provided by RefSeq, Jul 2008]
Protein type: Secreted, signal peptide; Secreted; EC 1.11.1.9; Other Amino Acids Metabolism - glutathione; Lipid Metabolism - arachidonic acid; Oxidoreductase
Chromosomal Location of Human Ortholog: 6p22.1
Cellular Component: extracellular region
Molecular Function: glutathione peroxidase activity
Biological Process: response to oxidative stress
Research Articles on GPX6
1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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