Anti -NMT1, NT (Glycylpeptide N-tetradecanoyltransferase 1, Peptide N-myristoyltransferase 1, Myristoyl-CoA:protein N-myristoyltransferase 1, NMT 1, Type I N-myristoyltransferase, NMT)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 17; NC_000017.10 (43138680..43186384). Location: 17q21.31

Polyclonal

IgG

Rabbit

Recognizes human NMT1.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-NMT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498aa of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.

Antibodies; Abs to Enzymes

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Immunohistochemistry: 1:50-1:100

56,806 Da[Similar Products]

N-myristoyltransferase 1

glycylpeptide N-tetradecanoyltransferase 1; NMT 1; long form, NMT-L; alternative, short form NMT-S; type I N-myristoyltransferase; peptide N-myristoyltransferase 1; myristoyl-CoA:protein N-myristoyltransferase 1

Glycylpeptide N-tetradecanoyltransferase 1

NMT??[Similar Products]

NMT1_HUMAN

Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM]

NMT1: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Belongs to the NMT family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.3.1.97; Transferase; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: extrinsic to membrane; cytoplasm; plasma membrane; cell junction; cytosol; actin cytoskeleton

Molecular Function: glycylpeptide N-tetradecanoyltransferase activity

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; viral reproduction; in utero embryonic development; apoptosis; N-terminal peptidyl-glycine N-myristoylation

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