Full Product Name
RABBIT ANTI IRAK4
Product Gene Name
anti-IRAK4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NWZ3
Form/Format
Purified IgG - liquid
Concentration
IgG concentration 0.5 mg/ml (lot specific)
Preservative Stabilisers
30% Glycerol, 0.5% Bovine Serum Albumin, 0.01% Thiomersal
Buffer Solution
Phosphate buffered saline
Preparation and Storage
Store at -20 degree C Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch
Other Notes
Small volumes of anti-IRAK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IRAK4 antibody
Rabbit anti IRAK4 antibody recognizes integrin-1 receptor-associated kinase 4 (IRAK4). IRAK4 is an important mediator in the signal transduction of toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family members. IRAK4 functions in this signal transduction pathway by binding to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. IRAK4 is a key activator of TLR-mediated signal transductions and has crucial roles in innate immune responses. It is expressed by the liver, kidneys and skeletal muscle.
Applications Tested/Suitable for anti-IRAK4 antibody
Western Blot (WB)
Application Notes for anti-IRAK4 antibody
Western Blot: 0.5; 4.0 ug/ml
Western Blot (WB) of anti-IRAK4 antibody
Western blot analysis of HeLa cell lysate probed with Rabbit anti IRAK4 antibody
NCBI/Uniprot data below describe general gene information for IRAK4. It may not necessarily be applicable to this product.
NCBI Accession #
Q9NWZ3.1
[Other Products]
UniProt Primary Accession #
Q9NWZ3
[Other Products]
UniProt Secondary Accession #
Q69FE1; Q8TDF7; Q9Y589[Other Products]
UniProt Related Accession #
Q9NWZ3[Other Products]
Molecular Weight
37,674 Da
NCBI Official Full Name
Interleukin-1 receptor-associated kinase 4
NCBI Official Synonym Full Names
interleukin 1 receptor associated kinase 4
NCBI Official Symbol
IRAK4??[Similar Products]
NCBI Official Synonym Symbols
IPD1; REN64; IRAK-4; NY-REN-64
??[Similar Products]
NCBI Protein Information
interleukin-1 receptor-associated kinase 4
UniProt Protein Name
Interleukin-1 receptor-associated kinase 4
UniProt Synonym Protein Names
Renal carcinoma antigen NY-REN-64
Protein Family
Interleukin-1 receptor-associated kinase
UniProt Gene Name
IRAK4??[Similar Products]
UniProt Synonym Gene Names
IRAK-4??[Similar Products]
UniProt Entry Name
IRAK4_HUMAN
NCBI Summary for IRAK4
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for IRAK4
IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.
Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; TKL group; IRAK family
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: cytoplasm; cytosol; endosome membrane; extracellular space; nucleus; plasma membrane
Molecular Function: ATP binding; interleukin-1 receptor binding; magnesium ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: cytokine and chemokine mediated signaling pathway; cytokine production; innate immune response; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; neutrophil mediated immunity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of smooth muscle cell proliferation; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
Research Articles on IRAK4
1. Src, Syk, IRAK1, and IRAK4 have roles in anti-inflammatory responses mediated by dietary flavonoid Kaempferol
Precautions
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Disclaimer
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