Full Product Name
IRAK4 Antibody - N-terminal region
Product Gene Name
anti-IRAK4 antibody
[Similar Products]
Product Synonym Gene Name
IRAK4[Similar Products]
Antibody/Peptide Pairs
IRAK4 peptide (MBS3244384) is used for blocking the activity of IRAK4 antibody (MBS3219505)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: VQQKQMPFCD KDRTLMTPVQ NLEQSYMPPD SSSPENKSLE VSDTRFHSFS
3D Structure
ModBase 3D Structure for Q9NWZ3
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human IRAK4
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-IRAK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IRAK4 antibody
This is a rabbit polyclonal antibody against IRAK4. It was validated on Western Blot
Target Description: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-IRAK4 antibody
Polyclonal; Lymphocyte Signaling; Protein Kinases; Immunology; Disease Related;
Applications Tested/Suitable for anti-IRAK4 antibody
Western Blot (WB)
Western Blot (WB) of anti-IRAK4 antibody
Host: Rabbit
Target Name: IRAK4
Sample Type: Fetal Lung lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for IRAK4. It may not necessarily be applicable to this product.
NCBI Accession #
AAM15772
[Other Products]
UniProt Primary Accession #
Q9NWZ3
[Other Products]
UniProt Related Accession #
Q9NWZ3[Other Products]
NCBI Official Full Name
interleukin-1 receptor associated kinase 4
NCBI Official Synonym Full Names
interleukin 1 receptor associated kinase 4
NCBI Official Symbol
IRAK4??[Similar Products]
NCBI Official Synonym Symbols
IPD1; REN64; IRAK-4; NY-REN-64
??[Similar Products]
NCBI Protein Information
interleukin-1 receptor-associated kinase 4
UniProt Protein Name
Interleukin-1 receptor-associated kinase 4
UniProt Synonym Protein Names
Renal carcinoma antigen NY-REN-64
Protein Family
Interleukin-1 receptor-associated kinase
UniProt Gene Name
IRAK4??[Similar Products]
UniProt Synonym Gene Names
IRAK-4??[Similar Products]
UniProt Entry Name
IRAK4_HUMAN
NCBI Summary for IRAK4
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for IRAK4
IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; TKL group; IRAK family
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: extracellular space; cytoplasm; plasma membrane; endosome membrane; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of smooth muscle cell proliferation; cytokine and chemokine mediated signaling pathway; cytokine production; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
Research Articles on IRAK4
1. rs4251545 of IRAK4 (p.Ala428Thr) modified the susceptibility to HBV-related HCC via increased proliferation rate and reduced production of inflammatory cytokines and chemokines
Precautions
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Disclaimer
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