Product Name
IRAK4, Polyclonal Antibody
Popular Item
Full Product Name
IRAK4 Antibody
Product Synonym Names
IPD1; NY-REN-64; REN64
Product Gene Name
anti-IRAK4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of IRAK4
Calculated Molecular Weight: 52kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34469 / sc-34470 / sc-99154
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-IRAK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IRAK4 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-IRAK4 antibody
WB: 1:200-1:1000
Testing Data of anti-IRAK4 antibody
NCBI/Uniprot data below describe general gene information for IRAK4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001107654.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001114182.2
[Other Products]
UniProt Secondary Accession #
Q69FE1; Q8TDF7; Q9Y589[Other Products]
UniProt Related Accession #
Q9NWZ3[Other Products]
Molecular Weight
37,674 Da
NCBI Official Full Name
interleukin-1 receptor-associated kinase 4 isoform a
NCBI Official Synonym Full Names
interleukin-1 receptor-associated kinase 4
NCBI Official Symbol
IRAK4??[Similar Products]
NCBI Official Synonym Symbols
IPD1; REN64; IRAK-4; NY-REN-64
??[Similar Products]
NCBI Protein Information
interleukin-1 receptor-associated kinase 4; renal carcinoma antigen NY-REN-64
UniProt Protein Name
Interleukin-1 receptor-associated kinase 4
UniProt Synonym Protein Names
Renal carcinoma antigen NY-REN-64
Protein Family
Interleukin-1 receptor-associated kinase
UniProt Gene Name
IRAK4??[Similar Products]
UniProt Synonym Gene Names
IRAK-4??[Similar Products]
UniProt Entry Name
IRAK4_HUMAN
NCBI Summary for IRAK4
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for IRAK4
IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, TKL; TKL group; IRAK family
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: extracellular space; cytoplasm; plasma membrane; endosome membrane; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; cytokine production; protein amino acid phosphorylation; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
Research Articles on IRAK4
1. delineation of the latter responses identified a narrow repertoire of transcriptional programs affected by loss of MyD88 function or IRAK4 function
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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