Product Name
IRAK4, Polyclonal Antibody
Popular Item
Full Product Name
Phospho-IRAK4 (Thr345/Ser346) Antibody
Product Gene Name
anti-IRAK4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NWZ3
Species Reactivity
Rat, Human, Mouse
Specificity
Phospho-IRAK4 (Thr345/Ser346) Ab detects endogenous levels of IRAK4 only when phosphorylated at Thr345/Ser346.
Purity/Purification
The Ab is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and nonphospho- peptide affinity columns.
Concentration
1.0mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human Phospho-IRAK4 (Thr345/Ser346) .
Similarity
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Buffer
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM
NaCl, 0.02% sodium azide and 50% glycerol.
Preparation and Storage
Store at -20°C. Stable for 12 months from date of receipt
Other Notes
Small volumes of anti-IRAK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IRAK4 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-IRAK4 antibody
WB 1:1000-3000
IHC 1:200
Western blot (WB) of anti-IRAK4 antibody
Western blot analysis Phospho-IRAK4 (Thr345/Ser346) using293 whole cell lysates
NCBI/Uniprot data below describe general gene information for IRAK4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001107654.1
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NCBI GenBank Nucleotide #
NM_001114182.2
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UniProt Primary Accession #
Q9NWZ3
[Other Products]
UniProt Secondary Accession #
Q69FE1; Q8TDF7; Q9Y589[Other Products]
UniProt Related Accession #
Q9NWZ3[Other Products]
NCBI Official Full Name
interleukin-1 receptor-associated kinase 4 isoform a
NCBI Official Synonym Full Names
interleukin 1 receptor associated kinase 4
NCBI Official Symbol
IRAK4??[Similar Products]
NCBI Official Synonym Symbols
IPD1; REN64; IRAK-4; NY-REN-64
??[Similar Products]
NCBI Protein Information
interleukin-1 receptor-associated kinase 4
UniProt Protein Name
Interleukin-1 receptor-associated kinase 4
UniProt Synonym Protein Names
Renal carcinoma antigen NY-REN-64
Protein Family
Interleukin-1 receptor-associated kinase
UniProt Gene Name
IRAK4??[Similar Products]
UniProt Synonym Gene Names
IRAK-4??[Similar Products]
NCBI Summary for IRAK4
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for IRAK4
IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.
Protein type: EC 2.7.11.1; IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane
Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: innate immune response; MyD88-dependent toll-like receptor signaling pathway; neutrophil mediated immunity; positive regulation of I-kappaB kinase/NF-kappaB cascade; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
Research Articles on IRAK4
1. The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95%) [20.1, 34.7 %]. A model to predict the inflammatory response in the maxillary sinus in the presence etiological factors of dental origin was constructed.
Precautions
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Disclaimer
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