Product Name
Irak4, Polyclonal Antibody
Popular Item
Full Product Name
Mouse Irak4 Antibody (C-term)
Product Synonym Names
Interleukin-1 receptor-associated kinase 4; IRAK-4; Irak4
Product Gene Name
anti-Irak4 antibody
[Similar Products]
Antibody/Peptide Pairs
Irak4 peptide (MBS9220504) is used for blocking the activity of Irak4 antibody (MBS9213464)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
422-449
3D Structure
ModBase 3D Structure for Q8R4K2
Specificity
This Mouse Irak4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 422-449 amino acids from the C-terminal region of mouse Irak4.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-Irak4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Irak4 antibody
Irak4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1 (By similarity).
Product Categories/Family for anti-Irak4 antibody
Cardiovascular; Immunology; Signal Transduction
Applications Tested/Suitable for anti-Irak4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-Irak4 antibody
WB~~1:1000
Western Blot (WB) of anti-Irak4 antibody
Mouse Irak4 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the Irak4 antibody detected the Irak4 protein (arrow).
NCBI/Uniprot data below describe general gene information for Irak4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_084202.2
[Other Products]
NCBI GenBank Nucleotide #
NM_029926.5
[Other Products]
UniProt Primary Accession #
Q8R4K2
[Other Products]
UniProt Secondary Accession #
Q80WW1[Other Products]
UniProt Related Accession #
Q8R4K2[Other Products]
NCBI Official Full Name
interleukin-1 receptor-associated kinase 4
NCBI Official Synonym Full Names
interleukin-1 receptor-associated kinase 4
NCBI Official Symbol
Irak4??[Similar Products]
NCBI Official Synonym Symbols
IRAK-4; NY-REN-64; 8430405M07Rik; 9330209D03Rik
??[Similar Products]
NCBI Protein Information
interleukin-1 receptor-associated kinase 4
UniProt Protein Name
Interleukin-1 receptor-associated kinase 4
Protein Family
Interleukin-1 receptor-associated kinase
UniProt Gene Name
Irak4??[Similar Products]
UniProt Synonym Gene Names
IRAK-4??[Similar Products]
UniProt Entry Name
IRAK4_MOUSE
UniProt Comments for Irak4
IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; IRAK family
Cellular Component: extracellular space; cytoplasm; plasma membrane; intracellular; nucleus
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; magnesium ion binding; kinase activity; ATP binding; protein kinase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; immune system process; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; innate immune response; JNK cascade; cytokine production; signal transduction; phosphorylation; protein amino acid phosphorylation
Product References and Citations for anti-Irak4 antibody
Erdman, L.K., et al. J. Immunol. 183(10):6452-6459(2009)
Maekawa, Y., et al. Circulation 120(14):1401-1414(2009)
Bauernfeind, F.G., et al. J. Immunol. 183(2):787-791(2009)
Staschke, K.A., et al. J. Immunol. 183(1):568-577(2009)
Koziczak-Holbro, M., et al. Arthritis Rheum. 60(6):1661-1671(2009)
Research Articles on Irak4
1. Our results demonstrate that osteoclasts and FBGCs are reciprocally regulated and identify IRAK4 as a potential therapeutic target to inhibit stimulated osteoclastogenesis and rescue inhibited FBGC formation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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