Product Name
ATAD5/FRAG1, Polyclonal Antibody
Full Product Name
Goat anti-ATAD5/FRAG1 Antibody
Product Synonym Names
ATAD5; C17orf41; chromosome 17 open reading frame 41; FLJ12735; FRAG1; chromosome fragility associated gene 1; ATPase family, AAA domain containing 5; ATAD5 antibody; C17orf41 antibody; chromosome 17 open reading frame 41 antibody; FLJ12735 antibody; FRAG1 antibody; chromosome fragility associated gene 1 antibody; ATPase family; AAA domain containing 5 antibody; ATAD5 / FRAG1
Product Gene Name
anti-ATAD5 antibody
[Similar Products]
Product Synonym Gene Name
FRAG1[Similar Products]
Antibody/Peptide Pairs
ATAD5 / FRAG1 peptide (MBS425736) is used for blocking the activity of ATAD5/FRAG1 antibody (MBS420012)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
DNKIYPKNTK KKRVD
Species Reactivity
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-DNKIYPKNTKKKRVD, from the internal region of the protein sequence according to NP_079133.3.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ATAD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ATAD5 antibody
Peptide ELISA (EIA)
Application Notes for anti-ATAD5 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave an approx 50kDa band in lysates of all Human cell lines tested after 0. 03ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 208kDa according to NP_079133.3. The 50kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for ATAD5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_079133.3
[Other Products]
NCBI GenBank Nucleotide #
NM_024857.4
[Other Products]
UniProt Secondary Accession #
Q05DH0; Q69YR6; Q9H9I1[Other Products]
UniProt Related Accession #
Q96QE3[Other Products]
Molecular Weight
135,878 Da
NCBI Official Full Name
ATPase family AAA domain-containing protein 5
NCBI Official Synonym Full Names
ATPase family, AAA domain containing 5
NCBI Official Symbol
ATAD5??[Similar Products]
NCBI Official Synonym Symbols
ELG1; FRAG1; C17orf41
??[Similar Products]
NCBI Protein Information
ATPase family AAA domain-containing protein 5
UniProt Protein Name
ATPase family AAA domain-containing protein 5
UniProt Synonym Protein Names
Chromosome fragility-associated gene 1 protein
Protein Family
ATPase family AAA domain-containing protein
UniProt Gene Name
ATAD5??[Similar Products]
UniProt Synonym Gene Names
C17orf41; FRAG1??[Similar Products]
UniProt Entry Name
ATAD5_HUMAN
UniProt Comments for ATAD5
ATAD5: Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: nucleus
Molecular Function: ATP binding
Biological Process: response to DNA damage stimulus
Research Articles on ATAD5
1. Authors discuss many functions of Elg1 protein as embryonic lethal when lost in mice, as a tumor suppressor in mice and humans, interacts with human Fanconi Anemia pathway and may contribute to some of the phenotypes associated with neurofibromatosis. [Review]
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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