Full Product Name
ATAD5 Antibody
Product Synonym Names
ELG1; FRAG1; C17orf41
Product Gene Name
anti-ATAD5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96QE3
Specificity
The antibody detects endogenous levels of total ATAD5 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
2.4 mg/ml (lot specific)
Immunogen Description
Synthetic peptide corresponding to a region derived from internal residues of human ATPase family, AAA domain containing 5
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ATAD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATAD5 antibody
ATAD5 (ATPase family, AAA domain containing 5), also known as chromosome fragility-associated gene 1 protein, FRAG1 or ELG1, is a 1,844 amino acid nuclear protein that is involved in the DNA damage response and belongs to the AAA ATPase family. Existing as two alternatively spliced isoforms, ATAD5 interacts with Rad9 in growing cells where it assists in interactions between Rad9 and Bcl-2.
Product Categories/Family for anti-ATAD5 antibody
Total protein Ab
Applications Tested/Suitable for anti-ATAD5 antibody
Western Blot (WB)
Application Notes for anti-ATAD5 antibody
Western blotting: 1:200-1:1000
Testing Data of anti-ATAD5 antibody
Gel: 8%SDS-PAGE Lysate: 40ug A431 cell Primary antibody: 1/400 dilution Secondary antibody dilution: 1/8000 Exposure time: 15 seconds
NCBI/Uniprot data below describe general gene information for ATAD5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_079133.3
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NCBI GenBank Nucleotide #
NM_024857.4
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UniProt Primary Accession #
Q96QE3
[Other Products]
UniProt Secondary Accession #
Q05DH0; Q69YR6; Q9H9I1[Other Products]
UniProt Related Accession #
Q96QE3[Other Products]
Molecular Weight
135,878 Da
NCBI Official Full Name
ATPase family AAA domain-containing protein 5
NCBI Official Synonym Full Names
ATPase family, AAA domain containing 5
NCBI Official Symbol
ATAD5??[Similar Products]
NCBI Official Synonym Symbols
ELG1; FRAG1; C17orf41
??[Similar Products]
NCBI Protein Information
ATPase family AAA domain-containing protein 5
UniProt Protein Name
ATPase family AAA domain-containing protein 5
UniProt Synonym Protein Names
Chromosome fragility-associated gene 1 protein
Protein Family
ATPase family AAA domain-containing protein
UniProt Gene Name
ATAD5??[Similar Products]
UniProt Synonym Gene Names
C17orf41; FRAG1??[Similar Products]
UniProt Entry Name
ATAD5_HUMAN
UniProt Comments for ATAD5
ATAD5: Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: nucleus
Molecular Function: ATP binding
Biological Process: response to DNA damage stimulus
Research Articles on ATAD5
1. Authors discuss many functions of Elg1 protein as embryonic lethal when lost in mice, as a tumor suppressor in mice and humans, interacts with human Fanconi Anemia pathway and may contribute to some of the phenotypes associated with neurofibromatosis. [Review]
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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