Full Product Name
MTAP Antibody
Product Gene Name
anti-MTAP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13126
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-MTAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MTAP antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for MTAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002442.2
[Other Products]
NCBI GenBank Nucleotide #
NM_002451.3
[Other Products]
UniProt Primary Accession #
Q13126
[Other Products]
UniProt Secondary Accession #
Q5T3P3; Q9H010; I2G7M5; I2G7M6; I2G7M7; I2G7M8; I2G7M9; I2G7N0[Other Products]
UniProt Related Accession #
Q13126[Other Products]
Molecular Weight
26,278 Da
NCBI Official Full Name
S-methyl-5'-thioadenosine phosphorylase
NCBI Official Synonym Full Names
methylthioadenosine phosphorylase
NCBI Official Symbol
MTAP??[Similar Products]
NCBI Official Synonym Symbols
BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249
??[Similar Products]
NCBI Protein Information
S-methyl-5'-thioadenosine phosphorylase
UniProt Protein Name
S-methyl-5'-thioadenosine phosphorylase
UniProt Synonym Protein Names
5'-methylthioadenosine phosphorylase
UniProt Gene Name
MTAP??[Similar Products]
UniProt Synonym Gene Names
MTA phosphorylase; MTAP; MTAPase??[Similar Products]
NCBI Summary for MTAP
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
UniProt Comments for MTAP
MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC 2.4.2.28; Phosphorylase; Transferase
Chromosomal Location of Human Ortholog: 9p21.3
Cellular Component: cytoplasm; cytosol
Molecular Function: phosphorylase activity; protein binding; S-methyl-5-thioadenosine phosphorylase activity
Biological Process: methionine salvage; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine salvage
Research Articles on MTAP
1. methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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