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VDR, Polyclonal Antibody

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VDR, Polyclonal Antibody


VDR, Polyclonal Antibody  的詳細介紹
Product Name

VDR, Polyclonal Antibody

Full Product Name

VDR Antibody

Product Synonym Names
Vitamin D3 receptor; VDR,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; VDR; NR1I1
Product Gene Name

anti-VDR antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
277440
3D Structure
ModBase 3D Structure for P11473
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This VDR antibody is generated from rabbits immunized with a recombinant protein of human VDR.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Recombinant Protein
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-VDR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-VDR antibody
This gene encodes the nuclear hormone receptor for vitamin
D3. This receptor also functions as a receptor for the secondary
bile acid lithocholic acid. The receptor belongs to the family of
trans-acting transcriptional regulatory factors and shows sequence
similarity to the steroid and thyroid hormone receptors. Downstream
targets of this nuclear hormone receptor are principally involved
in mineral metabolism though the receptor regulates a variety of
other metabolic pathways, such as those involved in the immune
response and cancer. Mutations in this gene are associated with
type II vitamin D-resistant rickets. A single nucleotide
polymorphism in the initiation codon results in an alternate
translation start site three codons downstream. Alternative
splicing results in multiple transcript variants encoding the same
protein.
Product Categories/Family for anti-VDR antibody
Cancer; Signal Transduction
Applications Tested/Suitable for anti-VDR antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-VDR antibody
WB~~1:1000

Western Blot (WB) of anti-VDR antibody
VDR Antibody western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the VDR Antibody detected the VDR protein (arrow).
anti-VDR antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for VDR. It may not necessarily be applicable to this product.
NCBI GI #
4507883
NCBI GeneID
7421
NCBI Accession #
NP_000367.1 [Other Products]
NCBI Related Accession #
HumanNP_001017535.1; NP_001017536.1[Other Products]
NCBI GenBank Nucleotide #
NM_000376.2 [Other Products]
UniProt Primary Accession #
P11473 [Other Products]
UniProt Secondary Accession #
Q5PSV3; B2R5Q1; G3V1V9[Other Products]
UniProt Related Accession #
P11473[Other Products]
Molecular Weight
48289
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NCBI Official Full Name
vitamin D3 receptor isoform VDRA
NCBI Official Synonym Full Names
vitamin D (1,25- dihydroxyvitamin D3) receptor
NCBI Official Symbol
VDR??[Similar Products]
NCBI Official Synonym Symbols
NR1I1; PPP1R163
??[Similar Products]
NCBI Protein Information
vitamin D3 receptor
UniProt Protein Name
Vitamin D3 receptor
UniProt Synonym Protein Names
1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
Protein Family
Vitamin D3 receptor
UniProt Gene Name
VDR??[Similar Products]
UniProt Synonym Gene Names
NR1I1; VDR??[Similar Products]
UniProt Entry Name
VDR_HUMAN
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NCBI Summary for VDR
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
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UniProt Comments for VDR
VDR: Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Defects in VDR are the cause of rickets vitamin D- dependent type 2A (VDDR2A). A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: Transcription factor; Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 12q13.11

Cellular Component: nucleoplasm; nucleus; receptor complex

Molecular Function: retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; vitamin D3 receptor activity; transcription factor activity

Biological Process: lactation; transcription initiation from RNA polymerase II promoter; positive regulation of apoptosis involved in mammary gland involution; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; decidualization; signal transduction; intestinal absorption; cellular calcium ion homeostasis; negative regulation of cell proliferation; calcium ion transport; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transcription, DNA-dependent; skeletal development; positive regulation of keratinocyte differentiation

Disease: Vitamin D-dependent Rickets, Type 2a; Osteoporosis
Product References and Citations for anti-VDR antibody
An, B.S., et al. Mol. Cell. Biol. 30(20):4890-4900(2010)
Elnenaei, M.O., et al. Br. J. Nutr., 1-8 (2010) In press :
Forghani, N., et al. J. Pediatr. Endocrinol. Metab. 23(8):843-850(2010)
Alvarez-Nava, F., et al. J. Pediatr. Endocrinol. Metab. 23(8):773-782(2010)
Jurutka, P.W., et al. Proc. Natl. Acad. Sci. U.S.A. 93(8):3519-3524(1996)

Research Articles on VDR
1. This study shows an association between FokI polymorphism in the VDR gene and nasal carriage of Staphylococcus aureus in individuals with type 2 diabetes.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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