Product Name
MTAP, Polyclonal Antibody
Popular Item
Full Product Name
MTAP Antibody
Product Synonym Names
BDMF; c86fus; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP
Product Gene Name
anti-MTAP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2530186 Technical Datasheet
Technical Datasheet PDF
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human MTAP
Observed Molecular Weight: 31kDa
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-MTAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MTAP antibody
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
Applications Tested/Suitable for anti-MTAP antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MTAP antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Western Blot (WB) of anti-MTAP antibody
Western blot analysis of extracts of various cell lines, using MTAP antibody.

Immunohistochemistry of anti-MTAP antibody
Immunohistochemistry of paraffinembedded mouse liver with MTAP Polyclonal Antibody

NCBI/Uniprot data below describe general gene information for MTAP. It may not necessarily be applicable to this product.
NCBI Accession #
AAF82688.1
[Other Products]
UniProt Secondary Accession #
Q5T3P3; Q9H010; I2G7M5; I2G7M6; I2G7M7; I2G7M8; I2G7M9; I2G7N0[Other Products]
UniProt Related Accession #
Q13126[Other Products]
Molecular Weight
Calculated MW: 26kDa/30kDa/31kDa/32kDa/33kDa/36kDa/38kDa
Observed MW: 31kDa
NCBI Official Full Name
MTAP, partial
NCBI Official Synonym Full Names
methylthioadenosine phosphorylase
NCBI Official Symbol
MTAP??[Similar Products]
NCBI Official Synonym Symbols
BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249
??[Similar Products]
NCBI Protein Information
S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; MeSAdo phosphorylase; epididymis luminal protein 249
UniProt Protein Name
S-methyl-5'-thioadenosine phosphorylase
UniProt Synonym Protein Names
5'-methylthioadenosine phosphorylase
UniProt Gene Name
MTAP??[Similar Products]
UniProt Entry Name
MTAP_HUMAN
NCBI Summary for MTAP
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
UniProt Comments for MTAP
MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Protein type: EC 2.4.2.28; Amino Acid Metabolism - cysteine and methionine; Phosphorylase; Transferase
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: phosphorylase activity; S-methyl-5-thioadenosine phosphorylase activity
Biological Process: methylation; methionine salvage; sulfur amino acid metabolic process; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; response to testosterone stimulus; purine ribonucleoside salvage; polyamine metabolic process
Research Articles on MTAP
1. MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients.
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Disclaimer
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