BDMF; c86fus; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity purification

Store at -20 degree C. Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-MTAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western blot analysis of extracts of various cell lines, using MTAP antibody.

Immunohistochemistry of paraffinembedded mouse liver with MTAP Polyclonal Antibody

Calculated MW: 26kDa/30kDa/31kDa/32kDa/33kDa/36kDa/38kDa
Observed MW: 31kDa

methylthioadenosine phosphorylase

S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; MeSAdo phosphorylase; epididymis luminal protein 249

S-methyl-5'-thioadenosine phosphorylase

MTAP_HUMAN

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]

MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Protein type: EC 2.4.2.28; Amino Acid Metabolism - cysteine and methionine; Phosphorylase; Transferase

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: phosphorylase activity; S-methyl-5-thioadenosine phosphorylase activity

Biological Process: methylation; methionine salvage; sulfur amino acid metabolic process; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; response to testosterone stimulus; purine ribonucleoside salvage; polyamine metabolic process

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