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MTAP, Polyclonal Antibody

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產(chǎn)品名稱: MTAP, Polyclonal Antibody
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MTAP, Polyclonal Antibody


MTAP, Polyclonal Antibody  的詳細介紹
Product Name

MTAP, Polyclonal Antibody

Full Product Name

MTAP antibody

Product Synonym Names
Polyclonal MTAP; Anti-MTAP; MTAP; MSAP; MeSAdo phosphorylase; c86fus; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; S-methyl-5'-thioadenosine phosphorylase
Product Gene Name

anti-MTAP antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
112250
3D Structure
ModBase 3D Structure for Q13126
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
MTAP antibody was purified by antigen-affinity chromatography
Form/Format
Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration
1 mg/ml (lot specific)
Biological Significance
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-MTAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-MTAP antibody
Affinity purified Rabbit polyclonal MTAP antibody
Product Categories/Family for anti-MTAP antibody
Proteases, Inhibitors, & Enzymes; Purified Polyclonal Antibodies
Applications Tested/Suitable for anti-MTAP antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-MTAP antibody
IHC-P: 1:100-1:500
WB: 1:500-1:3000

Western Blot (WB) of anti-MTAP antibody
Western blot analysis of 50 ug of whole cell lysate (A: mouse liver) using a 12 % SDS PAGE gel and MTAP antibody at a dilution of 1:1000
anti-MTAP antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-MTAP antibody
Western blot analysis of 30 ug of whole cell lysate (A: A431) using a 12 % SDS PAGE gel and MTAP antibody at a dilution of 1:1000
anti-MTAP antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MTAP antibody
Immunohistochemical staining of paraffin-embedded SAS xenograft using MTAP antibody at a dilution of 1:500
anti-MTAP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MTAP. It may not necessarily be applicable to this product.
NCBI GI #
9082015
NCBI GeneID
4507
NCBI Accession #
AAF82688.1 [Other Products]
UniProt Primary Accession #
Q13126 [Other Products]
UniProt Secondary Accession #
Q5T3P3; Q9H010; I2G7M5; I2G7M6; I2G7M7; I2G7M8; I2G7M9; I2G7N0[Other Products]
UniProt Related Accession #
Q13126[Other Products]
Molecular Weight
31 kDa
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NCBI Official Full Name
MTAP, partial
NCBI Official Synonym Full Names
methylthioadenosine phosphorylase
NCBI Official Symbol
MTAP??[Similar Products]
NCBI Official Synonym Symbols
BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249
??[Similar Products]
NCBI Protein Information
S-methyl-5'-thioadenosine phosphorylase
UniProt Protein Name
S-methyl-5'-thioadenosine phosphorylase
UniProt Synonym Protein Names
5'-methylthioadenosine phosphorylase
UniProt Gene Name
MTAP??[Similar Products]
UniProt Synonym Gene Names
MTA phosphorylase; MTAP; MTAPase??[Similar Products]
UniProt Entry Name
MTAP_HUMAN
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NCBI Summary for MTAP
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
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UniProt Comments for MTAP
MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Protein type: EC 2.4.2.28; Amino Acid Metabolism - cysteine and methionine; Transferase; Phosphorylase

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: phosphorylase activity; S-methyl-5-thioadenosine phosphorylase activity

Biological Process: methylation; methionine salvage; sulfur amino acid metabolic process; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; response to testosterone stimulus; purine ribonucleoside salvage; polyamine metabolic process
Research Articles on MTAP
1. MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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