Polyclonal MTAP; Anti-MTAP; MTAP; MSAP; MeSAdo phosphorylase; c86fus; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; S-methyl-5'-thioadenosine phosphorylase

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

MTAP antibody was purified by antigen-affinity chromatography

Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.

1 mg/ml (lot specific)

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of anti-MTAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Affinity purified Rabbit polyclonal MTAP antibody

Proteases, Inhibitors, & Enzymes; Purified Polyclonal Antibodies

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 1:100-1:500
WB: 1:500-1:3000

Western blot analysis of 50 ug of whole cell lysate (A: mouse liver) using a 12 % SDS PAGE gel and MTAP antibody at a dilution of 1:1000

Western blot analysis of 30 ug of whole cell lysate (A: A431) using a 12 % SDS PAGE gel and MTAP antibody at a dilution of 1:1000

Immunohistochemical staining of paraffin-embedded SAS xenograft using MTAP antibody at a dilution of 1:500

31 kDa

methylthioadenosine phosphorylase

S-methyl-5'-thioadenosine phosphorylase

S-methyl-5'-thioadenosine phosphorylase

MTA phosphorylase; MTAP; MTAPase??[Similar Products]

MTAP_HUMAN

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]

MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Protein type: EC 2.4.2.28; Amino Acid Metabolism - cysteine and methionine; Transferase; Phosphorylase

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: phosphorylase activity; S-methyl-5-thioadenosine phosphorylase activity

Biological Process: methylation; methionine salvage; sulfur amino acid metabolic process; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; response to testosterone stimulus; purine ribonucleoside salvage; polyamine metabolic process

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