Product Name
MTAP, Blocking Peptide
Full Product Name
MTAP Blocking Peptide (N-term)
Product Synonym Names
S-methyl-5'-thioadenosine phosphorylase; 24228; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; MTAP; MSAP
Product Gene Name
MTAP blocking peptide
[Similar Products]
Product Synonym Gene Name
MSAP[Similar Products]
MTAP peptide (MBS9228920) is used for blocking the activity of MTAP antibody (MBS9209691)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13126
Specificity
The synthetic peptide sequence is selected from aa 23-37 of HUMAN MTAP
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm. Nucleus
Tissue Location
Ubiquitously expressed.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of MTAP blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MTAP blocking peptide
Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates.
NCBI/Uniprot data below describe general gene information for MTAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002442.2
[Other Products]
NCBI GenBank Nucleotide #
NM_002451.3
[Other Products]
UniProt Primary Accession #
Q13126
[Other Products]
UniProt Secondary Accession #
Q5T3P3; Q9H010; I2G7M5; I2G7M6; I2G7M7; I2G7M8; I2G7M9; I2G7N0[Other Products]
UniProt Related Accession #
Q13126[Other Products]
Molecular Weight
26,278 Da
NCBI Official Full Name
S-methyl-5'-thioadenosine phosphorylase
NCBI Official Synonym Full Names
methylthioadenosine phosphorylase
NCBI Official Symbol
MTAP??[Similar Products]
NCBI Official Synonym Symbols
BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249
??[Similar Products]
NCBI Protein Information
S-methyl-5'-thioadenosine phosphorylase
UniProt Protein Name
S-methyl-5'-thioadenosine phosphorylase
UniProt Synonym Protein Names
5'-methylthioadenosine phosphorylase
UniProt Gene Name
MTAP??[Similar Products]
UniProt Synonym Gene Names
MTA phosphorylase; MTAP; MTAPase??[Similar Products]
UniProt Entry Name
MTAP_HUMAN
NCBI Summary for MTAP
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
UniProt Comments for MTAP
MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Protein type: EC 2.4.2.28; Amino Acid Metabolism - cysteine and methionine; Phosphorylase; Transferase
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: cytoplasm; cytosol
Molecular Function: phosphorylase activity; protein binding; S-methyl-5-thioadenosine phosphorylase activity
Biological Process: methionine salvage; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine salvage
Research Articles on MTAP
1. MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors.
Precautions
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Disclaimer
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