Full Product Name
VDR antibody
Product Synonym Names
VDR; NR1I1; Vitamin D3 receptor; 1; 25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
Product Gene Name
anti-VDR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11473
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous level of total VDR antibody.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human VDR.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-VDR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-VDR antibody
The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. This antibody is a rabbit Primary antibodyto human VDR.
Product Categories/Family for anti-VDR antibody
Total protein Ab
Applications Tested/Suitable for anti-VDR antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-VDR antibody
Western blotting: 1:500 - 1:2000
Immunofluorescence: 1:50 - 1:200
Western Blot (WB) of anti-VDR antibody
Western blot analysis of extracts of T-47D cell lines, using VDR antibody.

Immunofluorescence (IF) of anti-VDR antibody
Immunofluorescence analysis of A549 cell using VDR antibody. Blue: DAPI for nuclear staining.

NCBI/Uniprot data below describe general gene information for VDR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000367.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000376.2
[Other Products]
UniProt Primary Accession #
P11473
[Other Products]
UniProt Secondary Accession #
Q5PSV3; B2R5Q1; G3V1V9[Other Products]
UniProt Related Accession #
P11473[Other Products]
NCBI Official Full Name
vitamin D3 receptor isoform VDRA
NCBI Official Synonym Full Names
vitamin D (1,25- dihydroxyvitamin D3) receptor
NCBI Official Symbol
VDR??[Similar Products]
NCBI Official Synonym Symbols
NR1I1; PPP1R163
??[Similar Products]
NCBI Protein Information
vitamin D3 receptor
UniProt Protein Name
Vitamin D3 receptor
UniProt Synonym Protein Names
1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
Protein Family
Vitamin D3 receptor
UniProt Gene Name
VDR??[Similar Products]
UniProt Synonym Gene Names
NR1I1; VDR??[Similar Products]
UniProt Entry Name
VDR_HUMAN
NCBI Summary for VDR
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
UniProt Comments for VDR
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Research Articles on VDR
1. Morbidly obese subjects underwent gastric bypass or sleeve gastrectomy. Patients bearing the unfavorable B allele lost less weight. Patients without secondary hyperparathyroidism but with the unfavorable B allele had in higher levels of parathormone.
Precautions
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