Full Product Name
CHAF1A Antibody
Product Gene Name
anti-CHAF1A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13111
Other Notes
Small volumes of anti-CHAF1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CHAF1A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005474.2
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NCBI GenBank Nucleotide #
NM_005483.2
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UniProt Primary Accession #
Q13111
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UniProt Secondary Accession #
Q6NXG5; Q7Z7K3; Q9UJY8[Other Products]
UniProt Related Accession #
Q13111[Other Products]
Molecular Weight
88,269 Da
NCBI Official Full Name
chromatin assembly factor 1 subunit A
NCBI Official Synonym Full Names
chromatin assembly factor 1 subunit A
NCBI Official Symbol
CHAF1A??[Similar Products]
NCBI Official Synonym Symbols
CAF1; P150; CAF-1; CAF1B; CAF1P150
??[Similar Products]
NCBI Protein Information
chromatin assembly factor 1 subunit A
UniProt Protein Name
Chromatin assembly factor 1 subunit A
UniProt Synonym Protein Names
Chromatin assembly factor I p150 subunit; CAF-I 150 kDa subunit; CAF-I p150; hp150
Protein Family
Chromatin assembly factor
UniProt Gene Name
CHAF1A??[Similar Products]
UniProt Synonym Gene Names
CAF; CAF1P150; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; hp150??[Similar Products]
NCBI Summary for CHAF1A
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]
UniProt Comments for CHAF1A
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci ().
Research Articles on CHAF1A
1. Chromatin reassembly during double-strand break repair was dependent on the HIRA histone chaperone that is specific to the replication-independent histone variant H3.3 and on CAF-1 that is specific to the replication-dependent canonical histones H3.1/H3.2.
Precautions
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Disclaimer
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