Product Name
CHAF1A, Polyclonal Antibody
Full Product Name
CHAF1A Polyclonal Antibody
Product Synonym Names
CAF 1; CAF 1 subunit A; CAF; CAF I 150 kDa subunit; CAF I p150; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; CAF1; CAF1A; CAF1B; CAF1P150; CHAF1A; Chromatin assembly factor 1 subunit A; Chromatin Assembly Factor 1 Subunit A p150; Chromatin assembly factor I (150 kDa); Chromatin assembly factor I 150 kDa; Chromatin assembly factor I p150 subunit; DCAF1; hp150; MGC71229; P150
Product Gene Name
anti-CHAF1A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13111
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration
1 mg/mL (lot specific)
Immunogen
Recombinant protein of human CHAF1A
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CHAF1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CHAF1A antibody
Cancer; Epigenetics and Nuclear Signaling
Applications Tested/Suitable for anti-CHAF1A antibody
Western Blot (WB)
Application Notes for anti-CHAF1A antibody
WB: 1:500-1:2000
Western Blot (WB) of anti-CHAF1A antibody
Western blot analysis of extracts of various cell lines, using CHAF1A antibody.
NCBI/Uniprot data below describe general gene information for CHAF1A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005474.2
[Other Products]
NCBI GenBank Nucleotide #
NM_005483.3
[Other Products]
UniProt Primary Accession #
Q13111
[Other Products]
UniProt Secondary Accession #
Q6NXG5; Q7Z7K3; Q9UJY8[Other Products]
UniProt Related Accession #
Q13111[Other Products]
Molecular Weight
Calculated: 84kDa; 88kDa; 106kDa
Observed: 160kDa
NCBI Official Full Name
chromatin assembly factor 1 subunit A
NCBI Official Synonym Full Names
chromatin assembly factor 1 subunit A
NCBI Official Symbol
CHAF1A??[Similar Products]
NCBI Official Synonym Symbols
CAF1; P150; CAF-1; CAF1B; CAF1P150
??[Similar Products]
NCBI Protein Information
chromatin assembly factor 1 subunit A
UniProt Protein Name
Chromatin assembly factor 1 subunit A
UniProt Synonym Protein Names
Chromatin assembly factor I p150 subunit; CAF-I 150 kDa subunit; CAF-I p150; hp150
Protein Family
Chromatin assembly factor
UniProt Gene Name
CHAF1A??[Similar Products]
UniProt Synonym Gene Names
CAF; CAF1P150; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; hp150??[Similar Products]
NCBI Summary for CHAF1A
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]
UniProt Comments for CHAF1A
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci ().
Research Articles on CHAF1A
1. CHAF1A and PCNA are highly expressed in cervical squamous cell carcinoma and associated with the malignancy
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
