Product Name
CHAF1B, cDNA Clone
Full Product Name
CHAF1B cDNA Clone
Product Gene Name
CHAF1B cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaaagtca tcacttgtga aatagcctgg cacaacaagg agcccgtgta cagcctggac ttccagcatg ggacggctgg gaggatccac agactggcgt ctgccggcgt ggacaccaat gtcaggatct ggaaggtaga aaagggacca gatggaaaag ccatcgtgga atttttgtcc aatcttgctc gtcataccaa agccgtcaat gttgtgcgtt tttctccaac tggggaaatt ttagcatcgg gaggagatga tgctgtcatc ctattgtgga aggtgaatga taacaaggag ccggagcaga tcgcttttca ggatgaggac gaggcccagc tgaacaagga gaactggacg gttgtgaaga ctctgcgggg ccacttagaa gatgtgtatg atatttgctg ggcaactgat gggaatttaa tggcttctgc ctctgtggat aacacagcca tcatatggga tgtcagcaaa ggacaaaaga tatcaatttt taatgaacat aaaagttatg tccaaggagt aacctgggac cctttgggtc aatatgttgc tactctgagc tgtgacaggg tgctgcgagt atacagtata cagaagaagc gtgtggcttt caatgtttcg aagatgctgt ctggaatagg ggctgaagga gaggcaagaa gctaccggat gtttcacgac gacagcatga agtctttctt ccgtagactg agtttcactc ccgacggatc tttgcttctc acgccagctg gatgtgtgga atctggtgaa aatgtaatga ataccactta tgttttctcc aggaagaatc ttaaaaggcc catcgctcat cttccatgtc ctggaaaagc cactcttgct gttcgctgct gtccggtcta ctttgaactg aggccagtgg tggaaacagg tgtggagctg atgagtctgc cctaccgcct ggtgtttgct gtggcctcgg aggattccgt gcttctgtat gacacccagc agtccttccc ttttggttac gtgtctaata tacattacca caccctcagt gacatttcat ggtccagcga tggtgccttc ctggccattt cttccacgga cggttactgc tcatttgtga catttgagaa agatgaactt ggaattcctt tgaaagagaa gccagttttg aacatgagaa ctcctgatac agcaaagaaa accaagagtc agacacatcg agggtcttcg ccaggaccca gaccggtaga gggaacccct gccagcagaa cccaagaccc cagcagcccc ggcacgactc cccctcaggc cagacaggcc ccagccccaa cagtcatcag ggaccctccc tccatcactc ctgctgtcaa aagccccttg ccggggcctt cggaggagaa gaccctgcag cccagtagtc aaaacacaaa agcccaccca tcccggaggg tcactctgaa cacactgcaa gcctggagca agacaacacc ccggagaata aacttaacac ccttaaagac ggacactcca ccaagttctg taccaaccag tgtgatttcc accccttcta cagaagaaat tcagtcagag acgcctggag acgctcaggg cagtccccca gagctaaagc ggcccagact cgatgaaaac aaaggaggca cggaaagtct ggacccttga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CHAF1B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CHAF1B. It may not necessarily be applicable to this product.
NCBI Accession #
BC021218
[Other Products]
UniProt Secondary Accession #
Q99548[Other Products]
UniProt Related Accession #
Q13112[Other Products]
Molecular Weight
61,493 Da
NCBI Official Full Name
Homo sapiens chromatin assembly factor 1, subunit B (p60), mRNA
NCBI Official Synonym Full Names
chromatin assembly factor 1 subunit B
NCBI Official Symbol
CHAF1B??[Similar Products]
NCBI Official Synonym Symbols
CAF1; MPP7; CAF-1; CAF1A; CAF1P60; CAF-IP60; MPHOSPH7
??[Similar Products]
NCBI Protein Information
chromatin assembly factor 1 subunit B
UniProt Protein Name
Chromatin assembly factor 1 subunit B
UniProt Synonym Protein Names
Chromatin assembly factor I p60 subunit; CAF-I 60 kDa subunit; CAF-I p60; M-phase phosphoprotein 7
Protein Family
Chromatin assembly factor
UniProt Gene Name
CHAF1B??[Similar Products]
UniProt Synonym Gene Names
CAF1A; CAF1P60; MPHOSPH7; MPP7; CAF-1 subunit B; CAF-I 60 kDa subunit; CAF-I p60??[Similar Products]
UniProt Entry Name
CAF1B_HUMAN
NCBI Summary for CHAF1B
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]
UniProt Comments for CHAF1B
CAF-1B: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. The CCR4-NOT complex functions as general transcription regulation complex. Belongs to the WD repeat HIR1 family.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 21q22.13
Cellular Component: cytosol; nuclear chromatin; nucleoplasm; protein complex
Molecular Function: chromatin binding; histone binding; unfolded protein binding
Biological Process: chromatin assembly; DNA replication-dependent nucleosome assembly; positive regulation of defense response to virus by host; protein complex assembly
Research Articles on CHAF1B
1. All the evaluated malignant tumors showed CAF-1 p60 overexpression, confirming the emerging role of CAF-1 p60 as a new proliferation and prognostic marker for cancer.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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