Full Product Name
CSTB Antibody Pair
Product Synonym Names
Cystatin-B; CST6; STFB; CSTB; CPI-B; Liver thiol proteinase inhibitor Stefin-B
Product Gene Name
CSTB antibody pair
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Matching Pairs
Antibody: CSTB (MBS7041692)
Standard: Cystatin-B (MBS717075)
Comments: Standards are recommendations only. Compatibility of the standards in the user developed application needs to be established and confirmed by the researcher.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Isotype
Capture: IgG
Detection: IgG
Host
Capture: Rabbit
Detection: Rabbit
Species Reactivity
Human, Mouse, Pig, Dog, Rabbit, Goat, Duck
Concentration
The concentrations and volumes of the antibodies may vary and be lot specific. Details will be on the vial labels. (lot specific)
Conjugation
Capture: Non-conjugated; Detection: Biotin conjugated
Storage Buffer
Capture: 50% Glycerol, 0.01M PBS, PH 7.4
Detection: 50% Glycerol, 0.01M PBS, PH 7.4
Other Note
Immunogen information is company proprietary information. Antibodies are sold as a pair and not available separately.
Preparation and Storage
Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze/thaw cycles. When stored properly, products should be stable for at least 5 months.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CSTB antibody pair vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for CSTB antibody pair
Sandwich ELISA (EIA)
Application Notes for CSTB antibody pair
We recommend using the capture antibody at a concentration of 0.2ug/ml and the detection antibody at a concentration of 0.1ug/ml.
NCBI/Uniprot data below describe general gene information for CSTB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000091.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000100.3
[Other Products]
UniProt Related Accession #
P04080[Other Products]
Molecular Weight
11,140 Da
NCBI Official Full Name
cystatin-B
NCBI Official Synonym Full Names
cystatin B
NCBI Official Symbol
CSTB??[Similar Products]
NCBI Official Synonym Symbols
PME; ULD; CST6; EPM1; STFB; EPM1A
??[Similar Products]
NCBI Protein Information
cystatin-B
UniProt Protein Name
Cystatin-B
UniProt Synonym Protein Names
CPI-B; Liver thiol proteinase inhibitor; Stefin-B
UniProt Gene Name
CSTB??[Similar Products]
UniProt Synonym Gene Names
CST6; STFB??[Similar Products]
UniProt Entry Name
CYTB_HUMAN
NCBI Summary for CSTB
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq, Jul 2008]
UniProt Comments for CSTB
CSTB: This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Defects in CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1). EPM1 is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The onset, occurring between 6 and 13 years of age, is characterized by convulsions. Myoclonus begins 1 to 5 years later. The twitchings occur predominantly in the proximal muscles of the extremities and are bilaterally symmetrical, although asynchronous. At first small, they become late in the clinical course so violent that the victim is thrown to the floor. Mental deterioration and eventually dementia develop. Belongs to the cystatin family.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cytoplasm; extracellular space; nucleolus
Molecular Function: cysteine protease inhibitor activity; endopeptidase inhibitor activity; protease binding
Biological Process: ***** locomotory behavior; negative regulation of peptidase activity; negative regulation of proteolysis
Disease: Myoclonic Epilepsy Of Unverricht And Lundborg
Research Articles on CSTB
1. Data shows that CYTB and ANXA4 overexpression may be involved in carcinogenesis and histopathological differentiation of ovarian clear cell carcinoma and suggest they may serve as a potential diagnostic biomarkers.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
