Product Name
CCKAR, Blocking Peptide
Product Synonym Names
Cholecystokinin receptor type A; CCK-A receptor; CCK-AR; Cholecystokinin-1 receptor; CCK1-R; CCKAR; CCKRA
Product Gene Name
CCKAR blocking peptide
[Similar Products]
Product Synonym Gene Name
CCKRA[Similar Products]
Antibody/Peptide Pairs
CCKAR peptide (MBS9224269) is used for blocking the activity of CCKAR antibody (MBS9209744)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P32238
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cell membrane; Multi-pass membrane protein.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of CCKAR blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CCKAR blocking peptide
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
NCBI/Uniprot data below describe general gene information for CCKAR. It may not necessarily be applicable to this product.
NCBI Accession #
P32238.1
[Other Products]
UniProt Primary Accession #
P32238
[Other Products]
UniProt Secondary Accession #
B2R9Z5[Other Products]
UniProt Related Accession #
P32238[Other Products]
Molecular Weight
47,841 Da
NCBI Official Full Name
Cholecystokinin receptor type A
NCBI Official Synonym Full Names
cholecystokinin A receptor
NCBI Official Symbol
CCKAR??[Similar Products]
NCBI Official Synonym Symbols
CCK-A; CCK1R; CCKRA; CCK1-R
??[Similar Products]
NCBI Protein Information
cholecystokinin receptor type A
UniProt Protein Name
Cholecystokinin receptor type A
UniProt Synonym Protein Names
Cholecystokinin-1 receptor; CCK1-R
Protein Family
Cholecystokinin receptor
UniProt Gene Name
CCKAR??[Similar Products]
UniProt Synonym Gene Names
CCKRA; CCK-A receptor; CCK-AR; CCK1-R??[Similar Products]
UniProt Entry Name
CCKAR_HUMAN
NCBI Summary for CCKAR
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]
UniProt Comments for CCKAR
CCKAR: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p15.2
Cellular Component: integral to plasma membrane; plasma membrane
Biological Process: digestion; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of hormone secretion
Research Articles on CCKAR
1. There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.