Full Product Name
MSX1/HOX7
Product Gene Name
anti-MSX1/HOX7 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P28360
Purity/Purification
Affinity Purified
Immunogen
Synthetic peptide: Peptide with sequence: TSLPLGVKVEDS-C, from the N Terminus of the protein sequence according to NP_002439.1.
Other Notes
Small volumes of anti-MSX1/HOX7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MSX1/HOX7 antibody
MSX1 is a transcriptional repressor that belongs to the Msh homeobox family. It plays a role in cranofacial development and, via an ionic hedgehog-controlled cascade that includes MSX1 acts in parallel with the Wnt1 network, establishes the midbrain dopaminergic progenitor domain, which gives rise to a neuronal population that is critical for normal function of the human brain. It is an excellent marker for this population of neural progenitors.
Pathologies in dopaminergic neurons result in a number of neurological diseases including Parkinson's Disease.
Applications Tested/Suitable for anti-MSX1/HOX7 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Immunohistochemistry (IHC) of anti-MSX1/HOX7 antibody
MSX1 staining of staining of paraffin embedded Human Prostate(dilution: 2.5ug/ml). Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on data-sheet.
NCBI/Uniprot data below describe general gene information for MSX1/HOX7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002439.2
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NCBI GenBank Nucleotide #
NM_002448.3
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UniProt Primary Accession #
P28360
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UniProt Related Accession #
P28360[Other Products]
NCBI Official Full Name
homeobox protein MSX-1
NCBI Official Synonym Full Names
msh homeobox 1
NCBI Official Symbol
MSX1??[Similar Products]
NCBI Official Synonym Symbols
HOX7; HYD1; ECTD3; STHAG1
??[Similar Products]
NCBI Protein Information
homeobox protein MSX-1
UniProt Protein Name
Homeobox protein MSX-1
UniProt Synonym Protein Names
Homeobox protein Hox-7; Msh homeobox 1-like protein
UniProt Gene Name
MSX1??[Similar Products]
UniProt Synonym Gene Names
HOX7??[Similar Products]
UniProt Entry Name
MSX1_HUMAN
NCBI Summary for MSX1/HOX7
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]
UniProt Comments for MSX1/HOX7
MSX1: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family.
Protein type: Motility/polarity/chemotaxis; DNA-binding
Chromosomal Location of Human Ortholog: 4p16.2
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus
Molecular Function: p53 binding
Biological Process: embryonic forelimb morphogenesis; negative regulation of striated muscle cell differentiation; transcription from RNA polymerase II promoter; muscle development; protein stabilization; in utero embryonic development; regulation of odontogenesis; mesenchymal cell proliferation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; palate development; middle ear morphogenesis; embryonic hindlimb morphogenesis; odontogenesis of dentine-containing teeth; anterior/posterior pattern formation; negative regulation of cell proliferation; pituitary gland development; midbrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell growth; positive regulation of BMP signaling pathway; negative regulation of apoptosis
Disease: Orofacial Cleft 5; Witkop Syndrome; Tooth Agenesis, Selective, 1
Research Articles on MSX1/HOX7
1. A novel mutation of MSX1 in oligodontia found in a Chinese pedigree inhibits odontogenesis of dental pulp stem cells via the ERK pathway.
Precautions
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