Pituitary homeobox 1; Hindlimb-expressed homeobox protein backfoot; PITX1; BFT; PTX1; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1

For Research Use Only. Not for use in diagnostic procedures.

One 96-Well Plate

Store at 4 degree C.

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Small volumes of PITX1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9500792 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the PITX1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PITX1. The ELISA analytical biochemical technique of the MBS9500792 kit is based on PITX1 antibody-PITX1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PITX1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PITX1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Cell Based ELISA Kit

34 kDa

paired like homeodomain 1

pituitary homeobox 1

Pituitary homeobox 1

BFT; PTX1??[Similar Products]

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]

PITX1: May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Defects in PITX1 are a cause of congenital clubfoot (CCF); also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e. inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait. Belongs to the paired homeobox family. Bicoid subfamily.

Protein type: Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytoplasm; nucleolus; nucleus; transcription factor complex

Molecular Function: DNA binding transcription factor activity; protein binding

Biological Process: anatomical structure morphogenesis; branchiomeric skeletal muscle development; cartilage development; embryonic hindlimb morphogenesis; myoblast cell fate commitment; negative regulation of transcription, DNA-dependent; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; skeletal system development; transcription from RNA polymerase II promoter

Disease: Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/or Mirror-image Polydactyly; Liebenberg Syndrome

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