Full Product Name
PITX1 antibody - middle region
Product Gene Name
anti-PITX1 antibody
[Similar Products]
Product Synonym Gene Name
BFT; CCF; POTX; PTX1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: YVPQFSGLVQ PYEDVYAAGY SYNNWAAKSL APAPLSTKSF TFFNSMSPLS
3D Structure
ModBase 3D Structure for P78337
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human PITX1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PITX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PITX1 antibody
This is a rabbit polyclonal antibody against PITX1. It was validated on Western Blot
Target Description: PITX1 is a member of the RIEG/PITX homeobox family, which is involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
Product Categories/Family for anti-PITX1 antibody
Polyclonal; Transcription Factor; Transcription Regulation; Transcription Regulation; Cell Biology; Developmental Biology; Apoptosis; Cell Structure; Transcription Factors;
Applications Tested/Suitable for anti-PITX1 antibody
Western Blot (WB)
Western Blot (WB) of anti-PITX1 antibody
Host: Mouse
Target Name: PITX1
Sample Tissue: Mouse Kidney
Antibody Dilution: 1ug/ml
Western Blot (WB) of anti-PITX1 antibody
WB Suggested Anti-PITX1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: THP-1 cell lysate
NCBI/Uniprot data below describe general gene information for PITX1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002644
[Other Products]
NCBI GenBank Nucleotide #
NM_002653
[Other Products]
UniProt Primary Accession #
P78337
[Other Products]
UniProt Related Accession #
P78337[Other Products]
NCBI Official Full Name
pituitary homeobox 1
NCBI Official Synonym Full Names
paired like homeodomain 1
NCBI Official Symbol
PITX1??[Similar Products]
NCBI Official Synonym Symbols
BFT; CCF; POTX; PTX1; LBNBG
??[Similar Products]
NCBI Protein Information
pituitary homeobox 1
UniProt Protein Name
Pituitary homeobox 1
UniProt Synonym Protein Names
Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1
Protein Family
Pituitary homeobox
UniProt Gene Name
PITX1??[Similar Products]
UniProt Synonym Gene Names
BFT; PTX1??[Similar Products]
UniProt Entry Name
PITX1_HUMAN
NCBI Summary for PITX1
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]
UniProt Comments for PITX1
PITX1: May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Defects in PITX1 are a cause of congenital clubfoot (CCF); also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e. inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait. Belongs to the paired homeobox family. Bicoid subfamily.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus
Biological Process: myoblast cell fate commitment; anatomical structure morphogenesis; transcription, DNA-dependent; pituitary gland development; cartilage development; branchiomeric skeletal muscle development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; embryonic hindlimb morphogenesis
Disease: Liebenberg Syndrome; Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/or Mirror-image Polydactyly
Research Articles on PITX1
1. PITX1 might serve as a potential biomarker for early detection and prognosis prediction of patients with lung adenocarcinoma.
Precautions
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Disclaimer
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