Full Product Name
MSX1 Antibody BIOTIN-Conjugated
Product Synonym Names
AA675338; AI324650; Homeobox protein Hox-7; Homeobox protein MSX 1; HOX 7; HYD 1; msh (Drosophila) homeo box homolog 1; Msh; MSX 1; OFC5; STHAG1 antibody
Product Gene Name
anti-MSX1 antibody
[Similar Products]
Matching Pairs
Antibody: MSX1 (MBS542142)
Positive Control: MSX1 (MBS542965)
Antibody/Peptide Pairs
MSX1 peptide (MBS544009) is used for blocking the activity of MSX1 antibody (MBS542142)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P28360
Species Reactivity
Human, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.50-0.65 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 40-90 on mouse Msx1 protein.
Expression
Expressed in the developing nail bed mesenchyme.
Molecular Function
Developmental protein, Repressor
Structure
Belongs to the Msh homeobox family
Subcellular Location
Nucleus
Preparation and Storage
-20? degree C for long term storage
Other Notes
Small volumes of anti-MSX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MSX1 antibody
BIOTIN-Conjugated MSX1 protein Antibody
Acts as a transcriptional repressor;play a role in limb-pattern formation, cranofacial development and odontogenesis
Applications Tested/Suitable for anti-MSX1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-MSX1 antibody
Dot Blot: 1:20,000-1:50,000
ELISA: 1:20,000-1:50,000
Western Blot: 1:500-1:750
NCBI/Uniprot data below describe general gene information for MSX1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH67353.1
[Other Products]
UniProt Primary Accession #
P28360
[Other Products]
UniProt Secondary Accession #
Q96NY4; A0SZU5; A8K3M1[Other Products]
UniProt Related Accession #
P28360[Other Products]
Molecular Weight
31,496 Da
NCBI Official Full Name
MSX1 protein
NCBI Official Synonym Full Names
msh homeobox 1
NCBI Official Symbol
MSX1??[Similar Products]
NCBI Official Synonym Symbols
HOX7; HYD1; ECTD3; STHAG1
??[Similar Products]
NCBI Protein Information
homeobox protein MSX-1
UniProt Protein Name
Homeobox protein MSX-1
UniProt Synonym Protein Names
Homeobox protein Hox-7; Msh homeobox 1-like protein
Protein Family
Homeobox protein
UniProt Gene Name
MSX1??[Similar Products]
UniProt Synonym Gene Names
HOX7??[Similar Products]
UniProt Entry Name
MSX1_HUMAN
NCBI Summary for MSX1
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]
UniProt Comments for MSX1
MSX1: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family.
Protein type: Motility/polarity/chemotaxis; DNA-binding
Chromosomal Location of Human Ortholog: 4p16.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: p53 binding
Biological Process: anterior/posterior pattern formation; cell morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; forebrain development; in utero embryonic development; mesenchymal cell proliferation; midbrain development; middle ear morphogenesis; muscle development; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of striated muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; palate development; positive regulation of BMP signaling pathway; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; regulation of odontogenesis; transcription from RNA polymerase II promoter
Disease: Orofacial Cleft 5; Tooth Agenesis, Selective, 1; Witkop Syndrome
Research Articles on MSX1
1. lysine to make hydrogen bond with its target nucleotide(s) of DNA.">The sequence dependence of local conformation of DNA enables MSX1 glutamine50>lysine to make hydrogen bond with its target nucleotide(s) of DNA.
Precautions
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Disclaimer
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