Product Name
MSX1, Blocking Peptide
Full Product Name
MSX1 Peptide
Product Gene Name
MSX1 blocking peptide
[Similar Products]
Product Synonym Gene Name
HOX7; HYD1; STHAG1[Similar Products]
MSX1 peptide (MBS3225465) is used for blocking the activity of MSX1 antibody (MBS3200410)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P28360
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of MSX1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MSX1 blocking peptide
This is a synthetic peptide designed for use in combination with anti-MSX1 antibody made
Target Description: Slightly proximal to the Huntington disease locus, the human MSX1 gene is deleted in patients with Wolf-Hirschhorn syndrome. This gene is also called HOX7. The Msx family of vertebrate HOX genes was originally isolated by homology to the Drosophila msh (muscle segment homeo box) gene. This is a candidate gene for human cleft palate.
Product Categories/Family for MSX1 blocking peptide
Peptide
Applications Tested/Suitable for MSX1 blocking peptide
Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MSX1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002439
[Other Products]
NCBI GenBank Nucleotide #
NM_002448
[Other Products]
UniProt Primary Accession #
P28360
[Other Products]
UniProt Related Accession #
P28360[Other Products]
NCBI Official Full Name
homeobox protein MSX-1
NCBI Official Synonym Full Names
msh homeobox 1
NCBI Official Symbol
MSX1??[Similar Products]
NCBI Official Synonym Symbols
HOX7; HYD1; ECTD3; STHAG1
??[Similar Products]
NCBI Protein Information
homeobox protein MSX-1
UniProt Protein Name
Homeobox protein MSX-1
UniProt Synonym Protein Names
Homeobox protein Hox-7; Msh homeobox 1-like protein
Protein Family
Homeobox protein
UniProt Gene Name
MSX1??[Similar Products]
UniProt Synonym Gene Names
HOX7??[Similar Products]
UniProt Entry Name
MSX1_HUMAN
NCBI Summary for MSX1
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]
UniProt Comments for MSX1
MSX1: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family.
Protein type: Motility/polarity/chemotaxis; DNA-binding
Chromosomal Location of Human Ortholog: 4p16.2
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus
Molecular Function: p53 binding
Biological Process: embryonic forelimb morphogenesis; negative regulation of striated muscle cell differentiation; transcription from RNA polymerase II promoter; muscle development; protein stabilization; in utero embryonic development; regulation of odontogenesis; mesenchymal cell proliferation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; palate development; middle ear morphogenesis; embryonic hindlimb morphogenesis; odontogenesis of dentine-containing teeth; anterior/posterior pattern formation; negative regulation of cell proliferation; pituitary gland development; midbrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell growth; positive regulation of BMP signaling pathway; negative regulation of apoptosis
Disease: Orofacial Cleft 5; Witkop Syndrome; Tooth Agenesis, Selective, 1
Research Articles on MSX1
1. T (c.610G>T) in MSX1 gene in one child.">60 child patients (age 13 to 17) with various types of tooth agenesis were examined. Whole gene sequences of PAX9, MSX1, AXIN2, EDA, EDAR and WNT10a genes were sequenced by next generation sequencing on the Illumina MiSeq platform. We found previously undescribed heterozygous nonsense mutation g.8177G>T (c.610G>T) in MSX1 gene in one child.
Precautions
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Disclaimer
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