Full Product Name
Goat Polyclonal to Human MSX1
Product Synonym Names
Anti-MSX1 Antibody (N-Terminus) IHC-plus; MSX1; ECTD3; Homeobox protein MSX-1; HOX7; Msh homeo box 1; Homeobox 7; OFC5; STHAG1; Msh homeobox homolog 1; Homeobox protein Hox-7; HYD1; Msh homeobox 1; Msh homeobox 1-like protein; Human MSX1
Product Gene Name
anti-MSX1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P28360
Species Reactivity
Gibbon, Bovine, Chimpanzee, Human, Monkey, Mouse, Orangutan, Pig, Rat
Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Immunogen Description
Synthetic peptide TSLPLGVKVEDS-C from the N-terminus of human MSX1 (NP_002439.2). Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Tamarin, Mouse, Rat, Elephant, Bovine, Pig (100%); Gorilla (92%).
Immunogen Type
Synthetic peptide
Immunogen
MSX1 antibody was raised against synthetic peptide TSLPLGVKVEDS-C from the N-terminus of human MSX1 (NP_002439.2). Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Tamarin, Mouse, Rat, Elephant, Bovine, Pig (100%); Gorilla (92%).
Antigen Modification
N-Terminus
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-MSX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MSX1 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-MSX1 antibody
ELISA (1:16000), IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Immunohistochemistry (IHC) of anti-MSX1 antibody
Anti-MSX1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
NCBI/Uniprot data below describe general gene information for MSX1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002439.2
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NCBI GenBank Nucleotide #
NM_002448.3
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UniProt Primary Accession #
P28360
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UniProt Secondary Accession #
Q96NY4; A0SZU5; A8K3M1[Other Products]
UniProt Related Accession #
P28360[Other Products]
Molecular Weight
31,496 Da
NCBI Official Full Name
homeobox protein MSX-1
NCBI Official Synonym Full Names
msh homeobox 1
NCBI Official Symbol
MSX1??[Similar Products]
NCBI Official Synonym Symbols
HOX7; HYD1; ECTD3; STHAG1
??[Similar Products]
NCBI Protein Information
homeobox protein MSX-1; homeobox 7; msh homeo box 1; homeobox protein Hox-7; msh homeobox homolog 1; msh homeobox 1-like protein
UniProt Protein Name
Homeobox protein MSX-1
UniProt Synonym Protein Names
Homeobox protein Hox-7; Msh homeobox 1-like protein
Protein Family
Homeobox protein
UniProt Gene Name
MSX1??[Similar Products]
UniProt Synonym Gene Names
HOX7??[Similar Products]
UniProt Entry Name
MSX1_HUMAN
NCBI Summary for MSX1
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]
UniProt Comments for MSX1
MSX1: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family.
Protein type: Motility/polarity/chemotaxis; DNA-binding
Chromosomal Location of Human Ortholog: 4p16.2
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus
Molecular Function: p53 binding
Biological Process: embryonic forelimb morphogenesis; negative regulation of striated muscle cell differentiation; transcription from RNA polymerase II promoter; muscle development; protein stabilization; in utero embryonic development; regulation of odontogenesis; mesenchymal cell proliferation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; palate development; middle ear morphogenesis; embryonic hindlimb morphogenesis; odontogenesis of dentine-containing teeth; anterior/posterior pattern formation; negative regulation of cell proliferation; pituitary gland development; midbrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell growth; positive regulation of BMP signaling pathway; negative regulation of apoptosis
Disease: Orofacial Cleft 5; Witkop Syndrome; Tooth Agenesis, Selective, 1
Research Articles on MSX1
1. A) in exon 1 of MSX1 from family with oligodontia. produced termination codon in 1st exon and gene product (W139X) truncated at C terminus; entire homeodomain/MH4 absent. W139X MSX1 responsible for tooth agenesis.">novel nonsense mutation (c.416G>A) in exon 1 of MSX1 from family with oligodontia. produced termination codon in 1st exon and gene product (W139X) truncated at C terminus; entire homeodomain/MH4 absent. W139X MSX1 responsible for tooth agenesis.
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