Product Name
Neuromedin-K receptor (TACR3), Recombinant Protein
Full Product Name
Recombinant Human Neuromedin-K receptor (TACR3)
Product Synonym Names
Recombinant Neuromedin-K receptor (TACR3); Neuromedin-K receptor; NKR; NK-3 receptor; NK-3R Neurokinin B receptor Tachykinin receptor 3
Product Gene Name
TACR3 recombinant protein
[Similar Products]
Product Synonym Gene Name
TACR3; NK3R, TAC3R[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MATLPAAETW IDGGGGVGAD AVNLTASLAA GAATGAVETG WLQLLDQAGN LSSSPSALGL PVASPAPSQP WANLTNQFVQ PSWRIALWSL AYGVVVAVAV LGNLIVIWII LAHKRMRTVT NYFLVNLAFS DASMAAFNTL VNFIYALHSE WYFGANYCRF QNFFPITAVF ASIYSMTAIA VDRYMAIIDP LKPRLSATAT KIVIGSIWIL AFLLAFPQCL YSKTKVMPGR TLCFVQWPEG PKQHFTYHII VIILVYCFPL LIMGITYTIV GITLWGGEIP GDTCDKYHEQ LKAKRKVVKM MIIVVMTFAI CWLPYHIYFI LTAIYQQLNR WKYIQQVYLA SFWLAMSSTM YNPIIYCCLN KRFRAGFKRA FRWCPFIKVS SYDELELKTT RFHPNRQSSM YTVTRMESMT VVFDPNDADT TRSSRKKRAT PRDPSFNGCS RRNSKSASAT SSFISSPYTS VDEYS
Chromosome Location
Chromosome: 4; NC_000004.11 (104510625..104640973, complement). Location: 4q25
3D Structure
ModBase 3D Structure for P29371
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TACR3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TACR3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001050.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001059.2
[Other Products]
UniProt Primary Accession #
P29371
[Other Products]
UniProt Secondary Accession #
Q0P510[Other Products]
UniProt Related Accession #
P29371[Other Products]
Molecular Weight
52,202 Da[Similar Products]
NCBI Official Full Name
neuromedin-K receptor
NCBI Official Synonym Full Names
tachykinin receptor 3
NCBI Official Symbol
TACR3??[Similar Products]
NCBI Official Synonym Symbols
NKR; HH11; NK3R; NK-3R; TAC3RL
??[Similar Products]
NCBI Protein Information
neuromedin-K receptor; NK-3 receptor; neurokinin B receptor; neurokinin beta receptor
UniProt Protein Name
Neuromedin-K receptor
UniProt Synonym Protein Names
NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3
Protein Family
Neuromedin-K receptor
UniProt Gene Name
TACR3??[Similar Products]
UniProt Synonym Gene Names
NK3R; TAC3R; NKR; NK-3R??[Similar Products]
UniProt Entry Name
NK3R_HUMAN
NCBI Summary for TACR3
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
UniProt Comments for TACR3
TACR3: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nucleus
Molecular Function: protein binding; tachykinin receptor activity
Biological Process: tachykinin signaling pathway; hyperosmotic salinity response; regulation of dopamine metabolic process; response to morphine; positive regulation of heart rate; response to cocaine; positive regulation of blood pressure; response to estradiol stimulus; aging
Disease: Hypogonadotropic Hypogonadism 11 With Or Without Anosmia
Research Articles on TACR3
1. NKB/NK(3)R and kisspeptin/KISS1R are present in female peripheral reproductive tissues with colocalization of both systems in some non-neuronal cell populations of the human female genital tract.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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