Product Name
SC5DL, cDNA Clone
Full Product Name
SC5DL cDNA Clone
Product Gene Name
SC5DL cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggatcttg tactccgtgt tgcagattac tattttttta caccatacgt gtatccagcc acatggccag aagatgacat cttccgacaa gctattagtc ttctgattgt aacaaatgtt ggtgcttaca tcctttattt cttctgtgca acactgagct attattttgt cttcgatcat gcattaatga aacatccaca atttttaaag aatcaagtcc gtcgagagat taagtttact gtccaggcat tgccatggat aagtattctt actgttgcac tgttcttgct ggagataaga ggttacagca aattacatga tgacctagga gagtttccat atggattgtt tgaacttgtc gttagtataa tatctttcct ctttttcact gacatgttca tctactggat tcacagaggc cttcatcata gactggtata taagcgccta cataaacctc accatatttg gaagattcct actccatttg caagtcatgc ttttcaccct attgatggct ttcttcagag tctaccttac catatatacc cttttatctt tccattacac aaggtggttt atttaagtct gtacatcttg gttaatatct ggacaatttc cattcatgac ggtgattttc gtgtccccca aatcttacag ccatttatta atggctcagc tcatcataca gaccaccata tgttctttga ctataattat ggacaatatt tcactttgtg ggataggatt ggcggctcat tcaaaaatcc ttcatccttt gaggggaagg gaccgctcag ttatgtgaag gagatgacag agggaaagcg cagcagccat tcaggaaatg gctgtaagaa tgaaaaatta ttcaatggag agtttacaaa gactgaatag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SC5DL cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SC5DL. It may not necessarily be applicable to this product.
NCBI Accession #
BC012333
[Other Products]
UniProt Secondary Accession #
O00119; Q6GTM5; Q9UK15[Other Products]
UniProt Related Accession #
O75845[Other Products]
Molecular Weight
35,301 Da
NCBI Official Full Name
Homo sapiens sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like, mRNA
NCBI Official Synonym Full Names
sterol-C5-desaturase
NCBI Official Symbol
SC5D??[Similar Products]
NCBI Official Synonym Symbols
ERG3; S5DES; SC5DL
??[Similar Products]
NCBI Protein Information
lathosterol oxidase
UniProt Protein Name
Lathosterol oxidase
UniProt Synonym Protein Names
C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase
UniProt Gene Name
SC5D??[Similar Products]
UniProt Synonym Gene Names
SC5DL??[Similar Products]
UniProt Entry Name
SC5D_HUMAN
NCBI Summary for SC5DL
This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for SC5DL
SC5DL: Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. Defects in SC5DL are the cause of lathosterolosis (LATHST). This autosomal recessive disorder is characterized by a complex phenotype, including multiple congenital anomalies, mental retardation, and liver disease. Belongs to the sterol desaturase family.
Protein type: Membrane protein, integral; Lipid Metabolism - steroid biosynthesis; Oxidoreductase; Membrane protein, multi-pass; EC 1.14.21.6
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: endoplasmic reticulum membrane
Molecular Function: C-5 sterol desaturase activity
Biological Process: cholesterol biosynthetic process via desmosterol; cholesterol biosynthetic process via lathosterol; lipid metabolic process
Disease: Lathosterolosis
Research Articles on SC5DL
1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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