Product Name
Lathosterol oxidase (Sc5dl), Recombinant Protein
Full Product Name
Recombinant Mouse Lathosterol oxidase (Sc5dl)
Product Gene Name
Sc5dl recombinant protein
[Similar Products]
Product Synonym Gene Name
Sc5d[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-299aa; Full length protein
Sequence
MDLVLSAADY YFFTPYVYPA TWPEDNIIRQ TISLLIVTNL GAYILYFFCA TLSYYFVYDH SLMKHPQFLK NQVSREIVFT VKSLPWISIP TVSLFLLELR GYSKLYDDIG DFPNGWIHLM VSVVSFLFFT DMLIYRIHRG LHHRLVYKRI HKPHHIWKIP TPFASHAFHP VDGFLQSLPY HIYPFVFPLH KVVYLGLYVL VNVWTISIHD GDFRVPQILR PFINGSAHHT DHHMFFDYNY GQYFTLWDRI GGSFKHPSSF EGKGPHSYVK NMTEKESNSF AENGCKGKKV SNGEFTKNK
3D Structure
ModBase 3D Structure for O88822
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Sc5dl recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Sc5dl recombinant protein
Transmembrane Protein
Application Notes for Sc5dl recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Sc5dl. It may not necessarily be applicable to this product.
NCBI Accession #
NP_766357.1
[Other Products]
NCBI GenBank Nucleotide #
NM_172769.2
[Other Products]
UniProt Primary Accession #
O88822
[Other Products]
UniProt Secondary Accession #
Q8BGI0[Other Products]
UniProt Related Accession #
O88822[Other Products]
Molecular Weight
35,062 Da
NCBI Official Full Name
lathosterol oxidase
NCBI Official Synonym Full Names
sterol-C5-desaturase
NCBI Official Symbol
Sc5d??[Similar Products]
NCBI Official Synonym Symbols
Sc5dl; A830037K02; A830073K23Rik
??[Similar Products]
NCBI Protein Information
lathosterol oxidase
UniProt Protein Name
Lathosterol oxidase
UniProt Synonym Protein Names
C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase
UniProt Gene Name
Sc5d??[Similar Products]
UniProt Synonym Gene Names
Sc5dl??[Similar Products]
UniProt Entry Name
SC5D_MOUSE
UniProt Comments for Sc5dl
SC5DL: Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. Defects in SC5DL are the cause of lathosterolosis (LATHST). This autosomal recessive disorder is characterized by a complex phenotype, including multiple congenital anomalies, mental retardation, and liver disease. Belongs to the sterol desaturase family.
Protein type: EC 1.14.21.6; Oxidoreductase; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: endoplasmic reticulum; integral to membrane; intracellular membrane-bound organelle; membrane
Molecular Function: C-5 sterol desaturase activity; iron ion binding; oxidoreductase activity
Biological Process: cholesterol biosynthetic process via lathosterol; fatty acid biosynthetic process; lipid metabolic process; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process
Research Articles on Sc5dl
1. Data suggest that although cholesterol synthesis is impaired in both Dhcr7 mutant and Sc5d(-/-) embryonic brain, synthesis of nonsterol isoprenoids may be increased and thus contribute to Smith-Lemli-Opitz syndrome and lathosterolosis pathology.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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