Product Name
Glutamate receptor 1 (glr-1), Recombinant Protein
Full Product Name
Recombinant Caenorhabditis elegans Glutamate receptor 1 (glr-1), partial
Product Gene Name
glr-1 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
26-962
Sequence
YPSHIIIKSF GNNEEVSRVA LKAMEYTSDH INSRDDVPFK LAFDHRVVEE GAAVSWNMVN AVCDELKEGA MALLSSVDGK GREGIRGVSD ALEMPLVSLT ALSNDDHQQQ QFGNLFEVSV RPPISELLAD FIVHKGWGEV LVLIDPVHAS LHLPSLWRHL RTRTNTSVKA SMFDLPADEK QFEAYLMQFN MMRNNETNRI LIDCASPKRL KKLLINIRSA QFNQANYHYV LANYDFLPYD QEMFQNGNIN ISGFNIINKD GREYWSLKKH LKTSSSLGGG DDVSVEAAVG HDAMLVTWHG FAKCLQANDS LFHGTFRHRR FFNRGFPGIY CDPLSDRSHP NRPFSSFEHG KTIGVAFRNM KIGHKEGTLT GNIEFDRFGN RKNFDVSIVD LVSNTKATFN SKEVLAWRQG VGFFSNRTVA QHSRKSQNDH KDNQVIVLTN LVAPFVMIKR ECLEMANLTE CQGNNKFEGF CIDLLKLLAD KIEEFNYEIK LGTKAGSKQA DGSWDGMIGE LLSGRAHAVV ASLTINQERE RVVDFSKPFM TTGISIMIKK PDKQEFSVFS FMQPLSTEIW MYIIFAYIGV SVVIFLVSRF SPYEWRVEET SRGGFTISND FSVYNCLWFT LAAFMQQGTD ILPRSISGRI ASSAWWFFTM IIVSSYTANL AAFLTLEKMQ APIESVEDLA KQSKIKYGIQ GGGSTASFFK YSSVQIYQRM WRYMESQVPP VFVASYAEGI ERVRSHKGRY AFLLEATANE YENTRKPCDT MKVGANLNSI GYGIATPFGS DWKDHINLAI LALQERGELK KLENKWWYDR GQCDAGITVD GSSASLNLSK VAGIFYILMG GMVISMLAAL GEFLYRSRIE ARKSNSNSMV ANFAKNLKSA LSSQLRLSVE GGAVAQPGSQ SHNAIRRQQV AAFLPANEKE AFNNVDRPAN TLYNTAV
3D Structure
ModBase 3D Structure for P34299
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Caenorhabditis elegans
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of glr-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for glr-1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_498887.2
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NCBI GenBank Nucleotide #
NM_066486.6
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UniProt Primary Accession #
P34299
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UniProt Secondary Accession #
Q17363[Other Products]
UniProt Related Accession #
P34299[Other Products]
Molecular Weight
108,142 Da
NCBI Official Full Name
Glutamate receptor 1
NCBI Official Symbol
glr-1??[Similar Products]
NCBI Protein Information
Glutamate receptor 1
UniProt Protein Name
Glutamate receptor 1
Protein Family
Glutamate receptor
UniProt Gene Name
glr-1??[Similar Products]
UniProt Comments for glr-1
Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor (PubMed:7477293). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system (PubMed:7477293). The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists (PubMed:7477293). May contribute to a sensory discrimination between mechanical and chemical stimuli (PubMed:7477293). Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response (PubMed:27223098). In AIB interneurons, promotes omega turns, a movement that frequently follows backwards locomotion or "reversals" in response to environmental cues while possibly playing an inhibitory role in alternative neurons to inhibit omega turns (PubMed:27223098).
Research Articles on glr-1
1. We also assessed ionotropic glutamate receptor GLR-1 cell-specifically within AIB and determined that GLR-1 fine-tunes AIB activity to modify locomotion following reversal events. Our research highlights that signal integration underlying the initiation and fine-tuning of backwards locomotion is AIB and NPR-9 dependent, and has demonstrated the suitability of C. elegans for analysis of multisensory integration
Precautions
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Disclaimer
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