Chicken Ephrin type-B receptor 2 (EPHB2) ELISA kit; CAPB; DRT; EPHT3; ERK; Hek5; MGC87492; PCBC; Tyro5; elk-related tyrosine kinase; eph tyrosine kinase 3; ephrin type-B receptor 2; protein-tyrosine kinase HEK5; EPH receptor B2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of EPHB2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9320071 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the EPH receptor B2 (EPHB2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing EPHB2. The ELISA analytical biochemical technique of the MBS9320071 kit is based on EPHB2 antibody-EPHB2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EPHB2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EPHB2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

111,963 Da

EPH receptor B2

ephrin type-B receptor 2; EK5; cEK5; EPH-like kinase 5; embryo kinase 5 protein CEK5

Ephrin type-B receptor 2

CEK5; EK5; cEK5??[Similar Products]

EPHB2_CHICK

EphB2: a receptor tyrosine kinase of the Eph family. A receptor for ephrin-B family members. Activated EphB2 recruits RasGAP, down-regulating the Ras-Erk signaling axis and neurite retraction. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB2 interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. Point mutations seen in prostate cancer. Overexpressed and required for migration of glioblastoma. Overexpressed and correlated with poor survival in breast cancer. Overexpression and loss of heterozygosity seen in colorectal cancers. Target for immunoconjugate drug therapy .Three splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Tumor suppressor; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Eph family

Cellular Component: axon; integral to plasma membrane; dendrite; plasma membrane

Molecular Function: protein binding; transmembrane-ephrin receptor activity; ATP binding

Biological Process: axon guidance; positive regulation of synaptogenesis; peptidyl-tyrosine phosphorylation; axonal fasciculation; ephrin receptor signaling pathway; angiogenesis

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