Product Name
Capsaicin Receptor (TRPV1), Polyclonal Antibody
Full Product Name
Anti - Capsaicin Receptor (VR1, Transient receptor potential cation channel subfamily V member 1, TrpV1, osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like)
Product Synonym Names
Capsaicin Receptor (VR1, Transient receptor potential cation channel subfamily V member 1, TrpV1, osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like)
Product Gene Name
anti-TRPV1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (3468740..3512705, complement). Location: 17p13.2
3D Structure
ModBase 3D Structure for Q09HS5
Host
Host: Rabbit
Source: Rat
Specificity
Recognizes Vanilloid receptor like protein 1 (VRL-1). No significant sequence homology is found with VR1 or other proteins. Species crossreactivity: 100% conserved in mouse VRL-1 and growth factor regulated calcium channel. Only 52% homology with human VRL-1.
Purity/Purification
Serum
Form/Format
Serum
Supplied as a liquid, serum, 0.1% sodium azide.
Immunogen
Synthetic peptide (18aa) corresponding to the C-terminus of the rat VRL-1 protein.
Reconstitution
Reconstitute with 100ul of sterile dH2O.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add glycerol (40-50%) and store at -20 degree C. Do not freeze. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-TRPV1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TRPV1 antibody
Capsaicin receptor, termed vanilloid receptor subtype 1 (VR1), has been cloned from sensory neurons. VR1 protein is a heat-gated cation channel. VR1 is also activated by noxious heat (elevation in temperature causing pain) and high proton concentrations (pH <6.0). Rat VR1 encodes a membrane protein of 838aa (~95kD) with 6 transmembrane domains. VR1 expression is limited to small to medium diameter primary sensory neurons. Recently, a structural homolog of VR1, termed VRL-1 (VR1 like proteins; rat 761aa, human 764aa) have been cloned and characterized. There is ~49% identity between VRL-1 and VR1. In contrast to VR1, VRL-1 does not respond to capsaicin, acid or moderate heat. Instead, it is activated by high temperatures with a threshold of ~52°C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium to large-diameter neurons, and in many non-neuronal tissues (lung, spleen and intestine) that are unlikely to encounter temperatures of >50°C. It is possible that VRL-1 is also activated by stimuli other than heat.
Product Categories/Family for anti-TRPV1 antibody
Abs to Ion Channel
Applications Tested/Suitable for anti-TRPV1 antibody
ELISA, Western Blot
Application Notes for anti-TRPV1 antibody
Suitable for use in Western Blot and ELISA Other applications not tested.
Dilution: Western Blot: 1:1000-1:5000. Recombinant VR1 is ~90kD
ELISA: 1:10,000-1:50,000. Control peptide can be used to coat ELISA plates at 1ug/ml.
Optimal dilutions to be determined by the researcher.
NCBI/Uniprot data below describe general gene information for TRPV1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
Q09HS5
[Other Products]
UniProt Related Accession #
Q09HS5; Q3LU46; Q3LU47; Q52PU4; Q8IZY9; Q8NER1[Other Products]
Molecular Weight
94,846 Da[Similar Products]
NCBI Official Full Name
capsaicin receptor
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily V, member 1
NCBI Official Symbol
TRPV1??[Similar Products]
NCBI Official Synonym Symbols
VR1; DKFZp434K0220
??[Similar Products]
NCBI Protein Information
transient receptor potential cation channel subfamily V member 1; OTRPC1; capsaicin receptor; vanilloid receptor 1; osm-9-like TRP channel 1; vanilloid receptor subtype 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b
UniProt Protein Name
Transient receptor potential cation channel subfamily V member 1 transcript variant A
Protein Family
Transient receptor potential cation channel subfamily
UniProt Gene Name
TRPV1??[Similar Products]
UniProt Entry Name
Q09HS5_HUMAN
Product References and Citations for anti-TRPV1 antibody
??1. Caterina MJ et al (1997) Nature 398, 436-441.
??2. Kanzaki M et al (199) Nature Cell Biol. 1, 165-170.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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