Product Name
RAB27A, Monoclonal Antibody
Full Product Name
RAB27A Monoclonal Antibody
Product Synonym Names
GS2; GTP-binding protein Ram; HsT18676; MGC117246; Mutant Ras related protein Rab-27A; Rab-27; RAB-27A; RAB27; RAB27A; RAB27A member RAS oncogene family; RAM; Ras-related protein Rab-27A; Ras-related protein Rab27A; RB27A
Product Gene Name
anti-RAB27A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51159
Purity/Purification
Protein G purification
Concentration
1mg/mL (lot specific)
Immunogen
Fusion protein of RAB27A
Buffer
PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-RAB27A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RAB27A antibody
Rab27a is a member of a large family of Ras-related small GTPases. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Recent studies suggest that Rab27a is associated with melanosomes in pigmented cells and regulates melanosome transport via its interaction with actin-based cellular motors such as myosin Va and myosin VIIa. RAB27A is also required for regulated secretion in cytotoxic T lymphocytes. Rab27a is implicated in several diseases, including Griscelli syndrome, choroideremia, and the Hermansky-Pudlak syndrome mouse model, gunmetal.
Product Categories/Family for anti-RAB27A antibody
Cancer; Signal transduction
Applications Tested/Suitable for anti-RAB27A antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-RAB27A antibody
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:50-1:500
Western Blot (WB) of anti-RAB27A antibody
Western Blot analysis of K-562 cells using RAB27A Monoclonal Antibody at dilution of 1:1000
NCBI/Uniprot data below describe general gene information for RAB27A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004571.2
[Other Products]
NCBI GenBank Nucleotide #
NM_004580.4
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UniProt Primary Accession #
P51159
[Other Products]
UniProt Secondary Accession #
O00195; Q6FI40; Q9UIR9; Q9Y5U3[Other Products]
UniProt Related Accession #
P51159[Other Products]
Molecular Weight
Calculated: 25kDa
Observed: 27kDa
NCBI Official Full Name
ras-related protein Rab-27A
NCBI Official Synonym Full Names
RAB27A, member RAS oncogene family
NCBI Official Symbol
RAB27A??[Similar Products]
NCBI Official Synonym Symbols
GS2; RAM; RAB27; HsT18676
??[Similar Products]
NCBI Protein Information
ras-related protein Rab-27A
UniProt Protein Name
Ras-related protein Rab-27A
UniProt Synonym Protein Names
GTP-binding protein Ram
Protein Family
Ras-related protein
UniProt Gene Name
RAB27A??[Similar Products]
UniProt Synonym Gene Names
RAB27; Rab-27??[Similar Products]
NCBI Summary for RAB27A
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for RAB27A
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Research Articles on RAB27A
1. In comparison with the normal tissues, miR-182-5p is expressed at a higher level in gastric cancer (GC) tissues, while RAB27A is expressed at a lower level in cancerous tissues. The down-regulation of miR-182-5p and up-regulation of RAB27A can significantly decrease the viability, migration, invasion, and mitosis of HGC-27 cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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