Ras-related protein Rab-27A; RAB27A; GS2; HsT18676; RAB27; RAM; member RAS oncogene family

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody recognizes the human Rab27a protein.

Lyophilized serum

Lyophilized antibody can be kept at 4 degree C for up to 3 months and should be kept at-20 degree C for long-term storage.
To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20 degree C) or for long-term storage (-80 degree C).
For maximum recovery of product centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-Rab27a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Ras-related protein Rab-27a (Rab27a) belongs to the small GTPase superfamily. The protein is membrane-bound and is involved in protein transport and small GTPase-mediated signal transduction. Rab27a plays a role in cytotoxic granule exocytosis in lymphocytes. Rab27a is widely expressed with considerable expression in pancreatic islets and pituitary tissue, and low expression in the brain. Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2), a rare autosomal recessive disorder.

Immunoprecipitation (IP), Western Blot (WB)

If reconstituted in 100 muL: WB: 1:1000 (Recommended blocking solution: Donkey Serum 20%)
IP: Native conditions with 0.2% TritonX-100.

24,041 Da

RAB27A, member RAS oncogene family

ras-related protein Rab-27A

Ras-related protein Rab-27A

RAB27; Rab-27??[Similar Products]

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

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