Product Name
RAB27A, Monoclonal Antibody
Full Product Name
Anti-RAB27A Mouse mAb
Product Synonym Names
GS2; RAM; RAB27; HsT18676
Product Gene Name
anti-RAB27A antibody
[Similar Products]
Product Synonym Gene Name
GS2; RAM; RAB27; HsT18676[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Form/Format
Purified antibody in PBS with 0.05% sodium azide.
Immunogen
Purified recombinant fragment of human RAB27A (AA: FULL (1-221)) expressed in E Coli.
Other Notes
Small volumes of anti-RAB27A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RAB27A antibody
Entrez Summary: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
Applications Tested/Suitable for anti-RAB27A antibody
Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of anti-RAB27A antibody
Western blot analysis using RAB27A mAb against human RAB27A (AA
Western Blot (WB) of anti-RAB27A antibody
Western blot analysis using RAB27A mAb against HEK293 (1) and RAB27A (AA
Immunohistochemistry (IHC) of anti-RAB27A antibody
Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using RAB27A mouse mAb with DAB staining.
Immunohistochemistry (IHC) of anti-RAB27A antibody
Immunohistochemical analysis of paraffin-embedded liver cancer tissues using RAB27A mouse mAb with DAB staining.
NCBI/Uniprot data below describe general gene information for RAB27A. It may not necessarily be applicable to this product.
NCBI Accession #
CAG46494.1
[Other Products]
UniProt Secondary Accession #
O00195; Q6FI40; Q9UIR9; Q9Y5U3[Other Products]
UniProt Related Accession #
P51159[Other Products]
NCBI Official Full Name
RAB27A, partial
NCBI Official Synonym Full Names
RAB27A, member RAS oncogene family
NCBI Official Symbol
RAB27A??[Similar Products]
NCBI Official Synonym Symbols
GS2; RAM; RAB27; HsT18676
??[Similar Products]
NCBI Protein Information
ras-related protein Rab-27A
UniProt Protein Name
Ras-related protein Rab-27A
UniProt Synonym Protein Names
GTP-binding protein Ram
Protein Family
Ras-related protein
UniProt Gene Name
RAB27A??[Similar Products]
UniProt Synonym Gene Names
RAB27; Rab-27??[Similar Products]
NCBI Summary for RAB27A
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for RAB27A
RAB27A: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2). Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 15q21.3
Cellular Component: dendrite; late endosome; lysosome; melanosome; secretory granule
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding
Biological Process: antigen processing and presentation; exocytosis; melanosome localization; melanosome transport; positive regulation of exocytosis; positive regulation of phagocytosis; synaptic vesicle transport
Disease: Griscelli Syndrome, Type 2
Research Articles on RAB27A
1. decreased expression of Rab27A and Rab27B, especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.
Precautions
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