Full Product Name
COG5 Antibody
Product Synonym Names
Conserved oligomeric Golgi complex subunit 5; COG complex subunit 5; 13S Golgi transport complex 90 kDa subunit; GTC-90; Component of oligomeric Golgi complex 5; Golgi transport complex 1; COG5; GOLTC1; GTC90
Product Gene Name
anti-COG5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UP83
Purity/Purification
Antigen Affinity Purified
Immunogen
Recombinant human Conserved oligomeric Golgi complex subunit 5 protein (N-260AA)
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-162695
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-COG5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COG5 antibody
Required for normal Golgi function.
Applications Tested/Suitable for anti-COG5 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-COG5 antibody
Recommended dilution: IHC: 1:20-1:200
Immunohistochemistry (IHC) of anti-COG5 antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS7046506 at dilution 1:100
Immunohistochemistry (IHC) of anti-COG5 antibody
Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7046506 at dilution 1:100
NCBI/Uniprot data below describe general gene information for COG5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001154992.1
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NCBI GenBank Nucleotide #
NM_001161520.1
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UniProt Primary Accession #
Q9UP83
[Other Products]
UniProt Secondary Accession #
O14555; O95008; Q6NUL5; A4D0R6; A4D0R7[Other Products]
UniProt Related Accession #
Q9UP83[Other Products]
Molecular Weight
90,810 Da
NCBI Official Full Name
conserved oligomeric Golgi complex subunit 5 isoform 3
NCBI Official Synonym Full Names
component of oligomeric golgi complex 5
NCBI Official Symbol
COG5??[Similar Products]
NCBI Official Synonym Symbols
CDG2I; GTC90; GOLTC1
??[Similar Products]
NCBI Protein Information
conserved oligomeric Golgi complex subunit 5
UniProt Protein Name
Conserved oligomeric Golgi complex subunit 5
UniProt Synonym Protein Names
13S Golgi transport complex 90 kDa subunit; GTC-90; Component of oligomeric Golgi complex 5; Golgi transport complex 1
Protein Family
Conserved oligomeric Golgi complex
UniProt Gene Name
COG5??[Similar Products]
UniProt Synonym Gene Names
GOLTC1; GTC90; COG complex subunit 5; GTC-90??[Similar Products]
UniProt Entry Name
COG5_HUMAN
NCBI Summary for COG5
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]
UniProt Comments for COG5
COG5: Required for normal Golgi function. Defects in COG5 are the cause of congenital disorder of glycosylation type 2I (CDG2I). A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Congenital disorder of glycosylation type 2I is characterized by mild neurological impairments. Belongs to the COG5 family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: Golgi apparatus; Golgi membrane; Golgi transport complex; membrane; nucleoplasm; trans-Golgi network membrane
Molecular Function: protein binding
Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport
Disease: Congenital Disorder Of Glycosylation, Type Iii
Research Articles on COG5
1. Targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication
Precautions
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Disclaimer
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