Product Name
COG5, cDNA Clone
Full Product Name
COG5 cDNA Clone
Product Gene Name
COG5 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggctggg tgggcgggcg gcgccgggat tctgcgtcac cacctgggcg gagccgttct gctgctgacg acatcaaccc ggcacctgcc aacatggaag gtggcggcgg cagcgtcgct gtagctggcc tcggagctcg aggctctgga gcggctgcag ctacagtccg ggaacttctg caggacgggt gttatagtga ctttttaaac gaagactttg atgtaaagac ttatacttct caatctattc atcaagctgt aattgctgaa caactagcaa aacttgccca aggaatcagt cagttggaca gagaactaca cttacaggtt gttgcaagac atgaagattt actggcacaa gcaactggga ttgagtcgtt ggaaggtgtt cttcagatga tgcagacgag aattggggct ttacagggag ctgttgatag gataaaagca aaaattgttg aaccatacaa taagatagtt gcccggactg cacaactagc aagacttcag gttgcctgtg atttgcttcg gaggattatt cgtatcttga atctcagtaa gagactccaa ggacaactgc aagggggaag tagagagata acaaaagctg ctcagagtct caatgaactt gattatcttt ctcaaggaat agatctttct ggaatagaag tgatagaaaa tgatctactt tttattgcaa gagcccgact tgaagtggaa aatcaagcta agcgcctact agagcagggt ttggagactc agaatccaac tcaagtcgga acagctcttc aggttttcta taatcttgga actttgaagg atactattac cagtgttgtg gatggatatt gtgctacttt agaagaaaat atcaacagtg cattagacat aaaagttttg actcagcctt cccagtcagc tgtgagaggg ggacctggac gatctaccat gccaacccca ggaaatactg cagctttgcg tgcctcactc tggaccaata tggagaaact tatggatcat atttatgctg tttgtggaca ggtacaacat ctacaaaaag tattggccaa gaagagagat cctgtttctc acatttgttt cattgaagaa atagttaagg atggacaacc ggaaattttc tacacatttt ggaattcagt tactcaggca ctttcttctc aatttcatat ggcaacaaac tcttcgatgt ttttgaagca ggcatttgaa ggagaatacc ctaaattatt acgtctttat aatgacttat ggaagcgtct tcaacaatac agtcagcata tccaagggaa ttttaatgca agtggaacta cagacctcta tgttgaccta caacacatgg aagatgatgc acaagatata ttcataccaa aaaagccaga ttatgatcca gaaaaggctt tgaaagactc actacaaccc tatgaggctg cttatctatc aaaatcctta tctcgactct tcgatcctat caacttggtt tttcccccgg gtggtcgtaa tcctccttcc tctgatgaac ttgatggtat tattaaaact atagcaagtg aactaaatgt tgctgctgtt gatacaaacc tcacattagc tgtgtcaaaa aatgtggcaa agaccatcca gttatacagt gtaaaatcag agcagcttct ctccacacaa ggagatgcaa gtcaggtgat tgggcctctt actgaaggac agagaagaaa tgtggcagta gtgaattcat tgtataagtt gcaccaatca gtaacaaagg tggtttccag tcagagctca ttcccactgg cagctgagca aactataatt tcagctctaa aggctattca tgctcttatg gaaaatgctg tgcaaccctt actcacttct gtgggagatg ctatagaggc cataatcatc accatgcatc aagaagactt ttctgggtca ttatccagct caggaaaacc tgatgttcct tgttctctgt acatgaagga gctacaaggt ttcattgcca gagttatgag tgactatttt aaacactttg aatgcttgga ttttgtcttt gacaacactg aggctattgc ccaaagagct gttgaacttt ttatccgcca tgccagtctc ataagacctc ttggtgaagg tgggaaaatg cgacttgctg ctgattttgc acagatggag ttggctgtgg gtccattctg tagacgagta tctgatttag gaaagtccta tcggatgctg agatcattca gacctctgct cttccaggca agtgaacatg tagccagtag tcctgcattg ggggatgtga ttccgttcag catcattatt cagtttttgt tcacgagagc acccgctgaa ctgaaatctc ctttccagag ggcagagtgg tcccacacac gcttctctca gtggctggat gaccatccat ctgaaaagga caggctcctc ctcatcaggt aa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of COG5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for COG5. It may not necessarily be applicable to this product.
NCBI Accession #
BC068540
[Other Products]
UniProt Secondary Accession #
O14555; O95008; Q6NUL5; A4D0R6; A4D0R7[Other Products]
UniProt Related Accession #
Q9UP83[Other Products]
Molecular Weight
90,810 Da
NCBI Official Full Name
Homo sapiens component of oligomeric golgi complex 5, mRNA
NCBI Official Synonym Full Names
component of oligomeric golgi complex 5
NCBI Official Symbol
COG5??[Similar Products]
NCBI Official Synonym Symbols
CDG2I; GTC90; GOLTC1
??[Similar Products]
NCBI Protein Information
conserved oligomeric Golgi complex subunit 5
UniProt Protein Name
Conserved oligomeric Golgi complex subunit 5
UniProt Synonym Protein Names
13S Golgi transport complex 90 kDa subunit; GTC-90; Component of oligomeric Golgi complex 5; Golgi transport complex 1
Protein Family
Conserved oligomeric Golgi complex
UniProt Gene Name
COG5??[Similar Products]
UniProt Synonym Gene Names
GOLTC1; GTC90; COG complex subunit 5; GTC-90??[Similar Products]
UniProt Entry Name
COG5_HUMAN
NCBI Summary for COG5
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]
UniProt Comments for COG5
COG5: Required for normal Golgi function. Defects in COG5 are the cause of congenital disorder of glycosylation type 2I (CDG2I). A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Congenital disorder of glycosylation type 2I is characterized by mild neurological impairments. Belongs to the COG5 family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: Golgi apparatus; Golgi membrane; Golgi transport complex; membrane; nucleoplasm; trans-Golgi network membrane
Molecular Function: protein binding
Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport
Disease: Congenital Disorder Of Glycosylation, Type Iii
Research Articles on COG5
1. Targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication
Precautions
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Disclaimer
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