Ras-related protein Rab-27A; Rab-27; GTP-binding protein Ram; RAB27A; RAB27

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%, Protein G purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-RAB27A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

IHC: 1:20-1:200
IF: 1:50-1:200

Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7052353 at dilution of 1:100

Immunohistochemistry of paraffin-embedded human spleen tissue using MBS7052353 at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using MBS7052353 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

24,041 Da

RAB27A, member RAS oncogene family

ras-related protein Rab-27A

Ras-related protein Rab-27A

RAB27; Rab-27??[Similar Products]

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

RAB27A: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2). Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 15q21.3

Cellular Component: dendrite; late endosome; lysosome; melanosome; secretory granule

Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding

Biological Process: antigen processing and presentation; exocytosis; melanosome localization; melanosome transport; positive regulation of exocytosis; positive regulation of phagocytosis; synaptic vesicle transport

Disease: Griscelli Syndrome, Type 2

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