Full Product Name
EDNRB Rabbit Polyclonal
Product Gene Name
anti-EDNRB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Endothelin receptor type B
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-EDNRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-EDNRB antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for EDNRB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001188326.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001201397.1
[Other Products]
UniProt Secondary Accession #
O15343; Q59GB1; Q5W0G9; Q8NHM6; Q8NHM7; Q8NHM8; Q8NHM9; Q9UD23; Q9UQK3; A2A2Z8; A8K3T4[Other Products]
UniProt Related Accession #
P24530; AAB24922[Other Products]
Molecular Weight
59,480 Da
NCBI Official Full Name
endothelin B receptor isoform 3
NCBI Official Synonym Full Names
endothelin receptor type B
NCBI Official Symbol
EDNRB??[Similar Products]
NCBI Official Synonym Symbols
ETB; ET-B; ETB1; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2
??[Similar Products]
NCBI Protein Information
endothelin B receptor
UniProt Protein Name
Endothelin B receptor
UniProt Synonym Protein Names
Endothelin receptor non-selective type
Protein Family
Endothelin B receptor
UniProt Gene Name
EDNRB??[Similar Products]
UniProt Synonym Gene Names
ETRB; ET-B; ET-BR??[Similar Products]
UniProt Entry Name
EDNRB_HUMAN
NCBI Summary for EDNRB
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for EDNRB
ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.
Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q22
Cellular Component: cytosol; integral to plasma membrane; lipid raft; nuclear membrane; plasma membrane
Molecular Function: endothelin receptor activity; peptide hormone binding; protein binding; type 1 angiotensin receptor binding
Biological Process: aging; cell surface receptor linked signal transduction; cGMP-mediated signaling; elevation of cytosolic calcium ion concentration; enteric nervous system development; epithelial fluid transport; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); macrophage chemotaxis; melanocyte differentiation; negative regulation of adenylate cyclase activity; negative regulation of apoptosis; negative regulation of cellular protein metabolic process; negative regulation of neuron maturation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; neural crest cell migration; peripheral nervous system development; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; posterior midgut development; regulation of blood pressure; regulation of epithelial cell proliferation; regulation of fever; regulation of pH; regulation of sensory perception of pain; response to organic cyclic substance; response to pain; sensory perception of pain; vasoconstriction; vasodilation; vein smooth muscle contraction
Disease: Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2; Waardenburg Syndrome, Type 4a
Research Articles on EDNRB
1. EDNRB plays a key role in hypoxia tolerance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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