Product Name
EDNRB, Blocking Peptide
Full Product Name
EDNRB Antibody (C-term) Blocking Peptide
Product Synonym Names
Endothelin B receptor; ET-B; ET-BR; Endothelin receptor non-selective type; EDNRB; ETRB
Product Gene Name
EDNRB blocking peptide
[Similar Products]
Product Synonym Gene Name
ETRB[Similar Products]
Antibody/Peptide Pairs
EDNRB peptide (MBS9226332) is used for blocking the activity of EDNRB antibody (MBS9201556)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P24530
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human EDNRB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cell membrane; Multi-pass membrane protein.
Tissue Location
Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of EDNRB blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
EDNRB blocking peptide
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
NCBI/Uniprot data below describe general gene information for EDNRB. It may not necessarily be applicable to this product.
NCBI Accession #
P24530.1
[Other Products]
UniProt Primary Accession #
P24530
[Other Products]
UniProt Secondary Accession #
O15343; Q59GB1; Q5W0G9; Q8NHM6; Q8NHM7; Q8NHM8; Q8NHM9; Q9UD23; Q9UQK3; A2A2Z8; A8K3T4[Other Products]
UniProt Related Accession #
P24530; AAB24922[Other Products]
Molecular Weight
59,480 Da
NCBI Official Full Name
Endothelin B receptor
NCBI Official Synonym Full Names
endothelin receptor type B
NCBI Official Symbol
EDNRB??[Similar Products]
NCBI Official Synonym Symbols
ETB; ET-B; ETB1; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2
??[Similar Products]
NCBI Protein Information
endothelin B receptor
UniProt Protein Name
Endothelin B receptor
UniProt Synonym Protein Names
Endothelin receptor non-selective type
Protein Family
Endothelin B receptor
UniProt Gene Name
EDNRB??[Similar Products]
UniProt Synonym Gene Names
ETRB; ET-B; ET-BR??[Similar Products]
UniProt Entry Name
EDNRB_HUMAN
NCBI Summary for EDNRB
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for EDNRB
ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q22
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: endothelin receptor activity; peptide hormone binding; protein binding
Biological Process: cell surface receptor linked signal transduction; enteric nervous system development; macrophage chemotaxis; negative regulation of adenylate cyclase activity; negative regulation of cellular protein metabolic process; negative regulation of neuron maturation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; vasoconstriction; vein smooth muscle contraction
Disease: Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2; Waardenburg Syndrome, Type 4a
Research Articles on EDNRB
1. EDNRB plays a key role in hypoxia tolerance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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