Full Product Name
EDNRB antibody
Product Synonym Names
Polyclonal EDNRB; Anti-EDNRB; Endothelin B Receptor
Product Gene Name
anti-EDNRB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21451
Species Reactivity
Human, Mouse
Form/Format
Protein G purified and supplied in PBS, pH 7.5.
Concentration
Typically 1-5 mg/ml (lot specific)
Biological Significance
Endothelins are a family of peptides that are potent vasoconstrictors produced by mammalian vascular endothelial cells. The receptors for endothelins are widely expressed on tissues.
Immunogen
EDNRB antibody was raised in sheep using C-terminal peptide KANDHGYDNFRSSNN of rat ET(B) Receptor corresponding to amino acids 424 to 437 conjugated to KLH as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles.
Other Notes
Small volumes of anti-EDNRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EDNRB antibody
Sheep polyclonal EDNRB antibody
Product Categories/Family for anti-EDNRB antibody
Hormones & Steroids
Applications Tested/Suitable for anti-EDNRB antibody
User optimized
NCBI/Uniprot data below describe general gene information for EDNRB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_059029.1
[Other Products]
NCBI GenBank Nucleotide #
NM_017333.1
[Other Products]
UniProt Primary Accession #
P21451
[Other Products]
UniProt Related Accession #
P21451[Other Products]
Molecular Weight
49,455 Da
NCBI Official Full Name
endothelin B receptor
NCBI Official Synonym Full Names
endothelin receptor type B
NCBI Official Symbol
Ednrb??[Similar Products]
NCBI Official Synonym Symbols
Etb; Ednra
??[Similar Products]
NCBI Protein Information
endothelin B receptor
UniProt Protein Name
Endothelin B receptor
UniProt Synonym Protein Names
Endothelin receptor non-selective type
Protein Family
Endothelin B receptor
UniProt Gene Name
Ednrb??[Similar Products]
UniProt Synonym Gene Names
ET-B; ET-BR??[Similar Products]
UniProt Entry Name
EDNRB_RAT
UniProt Comments for EDNRB
ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1
Cellular Component: nuclear membrane; membrane; plasma membrane; integral to membrane; lipid raft
Molecular Function: G-protein coupled receptor activity; endothelin receptor activity; peptide hormone binding; receptor activity; type 1 angiotensin receptor binding
Biological Process: epithelial fluid transport; cGMP-mediated signaling; pigmentation during development; regulation of fever; response to lipopolysaccharide; response to pain; negative regulation of cellular protein metabolic process; negative regulation of transcription from RNA polymerase II promoter; sensory perception of pain; vein smooth muscle contraction; response to organic cyclic substance; enteric nervous system development; vasodilation; regulation of epithelial cell proliferation; elevation of cytosolic calcium ion concentration; regulation of blood pressure; positive regulation of cell proliferation; melanocyte differentiation; regulation of pH; neural crest cell migration; aging; posterior midgut development; vasoconstriction; macrophage chemotaxis; peripheral nervous system development; G-protein coupled receptor protein signaling pathway; negative regulation of neuron maturation; pigmentation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis
Research Articles on EDNRB
1. Mitogen-activating protein kinases (ERK1/2 and p38) and the downstream transcriptional factor NF-kappaB pathways were involved in cyclosporin A-induced upregulation of ETB receptor in arterial smooth muscle cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
