For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of PTPN14 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9356158 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tyrosine-Protein Phosphatase Non-Receptor Type 14 (PTPN14) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PTPN14. The ELISA analytical biochemical technique of the MBS9356158 kit is based on PTPN14 antibody-PTPN14 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PTPN14 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PTPN14. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

135,261 Da

protein tyrosine phosphatase, non-receptor type 14

tyrosine-protein phosphatase non-receptor type 14

Tyrosine-protein phosphatase non-receptor type 14

PEZ; PTPD2??[Similar Products]

PTN14_HUMAN

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

PTPN14: a non-receptor phospho-tyrosine protein phosphatase. Reported to be mutated in a small percentage of human cancers including colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. May play a role in liver metastases and tumour invasion in pancreatic cancer. Contains 1 FERM domain.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: cytoplasm; cytoskeleton; nucleoplasm; nucleus

Molecular Function: protein binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; transcription cofactor activity

Biological Process: lymphangiogenesis; negative regulation of cell proliferation; protein amino acid dephosphorylation; regulation of protein export from nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent

Disease: Choanal Atresia And Lymphedema

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