Product Name
ALG1, cDNA Clone
Popular Item
Full Product Name
ALG1 cDNA Clone
Product Gene Name
ALG1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggcct catgcttggt cctgctggcg ctgtgtctgc tgctgccgct gctgctgctg ggaggatgga agcgctggcg ccgggggcgg gcggcccggc atgtagtagc ggtggtgctg ggcgacgtgg gccgcagccc ccgtatgcag taccacgcgc tgtcgttggc catgcacggc ttctcggtga ccctcctggg gttctgcaac tccaaacccc atgatgagct cttgcagaac aacagaattc agattgtggg gttgacagaa cttcagagtc ttgcagttgg gccccgagtt ttccagtacg gagtcaaagt tgtacttcag gctatgtact tgctgtggaa gttgatgtgg agggagccag gtgcctatat ctttctccag aaccccccag gtctgcctag cattgctgtc tgctggttcg tgggctgcct ttgtggaagc aagctcgtca ttgactggca caactatggc tactccatca tgggtctggt gcatggcccc aaccatcccc tcgttctgct ggccaagtgg tacgagaagt tctttgggcg cctgtcccac ctgaacctgt gtgttaccaa tgctatgcga gaagacctgg cggataactg gcacatcagg gctgtgaccg tctacgacaa gcccgcatct ttctttaaag agacacctct ggacctgcag caccggctct tcatgaagct gggcagcatg cactctccgt tcagggcccg ctcagaacct gaggacccag tcacggagcg gtcggccttc acggagcggg atgctgggaa cgggctggtg acgcgtctcc gtgagcggcc agccctgctg gtcagcagca cgagctggac agaggacgaa gacttctcca tcctgctggc agctttagaa aagtttgaac aactgactct tgatggacac aaccttcctt ctctcgtctg tgtgataaca ggcaaagggc ctctgaggga gtattatagc cgcctcatcc accagaagca cttccagcac atccaggtct gcaccccctg gctggaggcc gaggactacc ccctgcttct agggtcggcg gacctgggtg tctgtctgca cacgtcctcc agtggcctgg acctgcccat gaaggtggtg gacatgttcg ggtgctgttt gcctgtgtgt gctgtgaact tcaagtgttt acatgagctg gtgaaacatg aagaaaatgg cctggtcttt gaggactcag aggaactggc agctcagctg cagatgcttt tctcaaactt tcctgatcct gcgggcaagc taaaccagtt ccggaagaac ctgcgggagt cgcagcagct ccgatgggat gagagctggg tgcagactgt gctccctttg gttatggaca cataa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ALG1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ALG1. It may not necessarily be applicable to this product.
NCBI Accession #
BC004402
[Other Products]
UniProt Secondary Accession #
Q6UVZ9; Q8N5Y4; Q9P2Y2; B4DP08[Other Products]
UniProt Related Accession #
Q9BT22[Other Products]
Molecular Weight
40,338 Da
NCBI Official Full Name
Homo sapiens asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
NCBI Official Symbol
ALG1??[Similar Products]
NCBI Official Synonym Symbols
HMT1; MT-1; CDG1K; HMAT1; HMT-1; Mat-1; hMat-1
??[Similar Products]
NCBI Protein Information
chitobiosyldiphosphodolichol beta-mannosyltransferase
UniProt Protein Name
Chitobiosyldiphosphodolichol beta-mannosyltransferase
UniProt Synonym Protein Names
Asparagine-linked glycosylation protein 1 homolog; Beta-1,4-mannosyltransferase; GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; Mannosyltransferase-1; MT-1; hMat-1
UniProt Gene Name
ALG1??[Similar Products]
UniProt Synonym Gene Names
HMAT1; HMT1; MT-1; hMat-1??[Similar Products]
UniProt Entry Name
ALG1_HUMAN
NCBI Summary for ALG1
The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008]
UniProt Comments for ALG1
ALG1: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. Defects in ALG1 are the cause of congenital disorder of glycosylation type 1K (CDG1K). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.
Protein type: Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Transferase; Endoplasmic reticulum; EC 2.4.1.142
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane
Molecular Function: chitobiosyldiphosphodolichol beta-mannosyltransferase activity; mannosyltransferase activity
Biological Process: dolichol-linked oligosaccharide biosynthetic process; lipopolysaccharide biosynthetic process
Disease: Congenital Disorder Of Glycosylation, Type Ik
Research Articles on ALG1
1. In title.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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