Product Name
PTPN14, Polyclonal Antibody
Popular Item
Full Product Name
PTPN14 Polyclonal Antibody
Product Synonym Names
PEZ; PTP36
Product Gene Name
anti-PTPN14 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15678
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human PTPN14
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-PTPN14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PTPN14 antibody
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.
Product Categories/Family for anti-PTPN14 antibody
Primary antibody
Applications Tested/Suitable for anti-PTPN14 antibody
Western Blot (WB)
Application Notes for anti-PTPN14 antibody
WB: 1:500 - 1:1000
Western Blot (WB) of anti-PTPN14 antibody
Western blot analysis of extracts of various cell lines, using PTPN14 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
NCBI/Uniprot data below describe general gene information for PTPN14. It may not necessarily be applicable to this product.
NCBI Accession #
Q15678.2
[Other Products]
UniProt Primary Accession #
Q15678
[Other Products]
UniProt Secondary Accession #
Q5VSI0[Other Products]
UniProt Related Accession #
Q15678[Other Products]
NCBI Official Full Name
Tyrosine-protein phosphatase non-receptor type 14
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 14
NCBI Official Symbol
PTPN14??[Similar Products]
NCBI Official Synonym Symbols
PEZ; PTP36
??[Similar Products]
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 14
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 14
UniProt Synonym Protein Names
Protein-tyrosine phosphatase pez
Protein Family
Tyrosine-protein phosphatase non-receptor
UniProt Gene Name
PTPN14??[Similar Products]
UniProt Synonym Gene Names
PEZ; PTPD2??[Similar Products]
NCBI Summary for PTPN14
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
UniProt Comments for PTPN14
PTPN14: a non-receptor phospho-tyrosine protein phosphatase. Reported to be mutated in a small percentage of human cancers including colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. May play a role in liver metastases and tumour invasion in pancreatic cancer. Contains 1 FERM domain.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 1q32.3-q41
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; transcription cofactor activity
Biological Process: lymphangiogenesis; negative regulation of cell proliferation; protein amino acid dephosphorylation; regulation of protein export from nucleus
Disease: Choanal Atresia And Lymphedema
Research Articles on PTPN14
1. PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells.
Precautions
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